A cell-based phenotypic library selection and screening approach for the de novo discovery of novel functional chimeric antigen receptors

Anti-tumor therapies that seek to exploit and redirect the cytotoxic killing and effector potential of autologous or syngeneic T cells have shown extraordinary promise and efficacy in certain clinical settings. Such cells, when engineered to express synthetic chimeric antigen receptors (CARs) acquir...

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Detalles Bibliográficos
Autores principales: Fierle, Julie K., Abram-Saliba, Johan, Atsaves, Vasileios, Brioschi, Matteo, de Tiani, Mariastella, Reichenbach, Patrick, Irving, Melita, Coukos, George, Dunn, Steven M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782825/
https://www.ncbi.nlm.nih.gov/pubmed/35064152
http://dx.doi.org/10.1038/s41598-022-05058-5

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