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Higher trait neuroticism is associated with greater fatty acid amide hydrolase binding in borderline and antisocial personality disorders
Borderline personality disorder (BPD) and antisocial personality disorder (ASPD) are the two most frequently diagnosed and researched DSM-5 personality disorders, and both are characterized by high levels of trait neuroticism. Fatty acid amide hydrolase (FAAH), an enzyme of the endocannabinoid syste...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782862/ https://www.ncbi.nlm.nih.gov/pubmed/35064143 http://dx.doi.org/10.1038/s41598-022-04789-9 |
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author | Kolla, Nathan J. Boileau, Isabelle Bagby, R. Michael |
author_facet | Kolla, Nathan J. Boileau, Isabelle Bagby, R. Michael |
author_sort | Kolla, Nathan J. |
collection | PubMed |
description | Borderline personality disorder (BPD) and antisocial personality disorder (ASPD) are the two most frequently diagnosed and researched DSM-5 personality disorders, and both are characterized by high levels of trait neuroticism. Fatty acid amide hydrolase (FAAH), an enzyme of the endocannabinoid system (ECS), has been linked to regulation of mood through modulation of anandamide, an endocannabinoid. We hypothesized that prefrontal cortex (PFC) FAAH binding would relate to trait neuroticism in personality disorders. Thirty-one individuals with personality disorders (20 with BPD and 11 with ASPD) completed the investigation. All participants completed the revised NEO Personality Inventory, which yields standardized scores (e.g., T scores) for the traits of neuroticism, openness, conscientiousness, agreeableness, and extraversion. All participants were medication free and were not utilizing illicit substances as determined by drug urinalysis. Additionally, none of the participants had a comorbid major depressive episode, bipolar disorder, psychotic disorder, or substance use disorder. Each participant underwent one [(11)C]CURB PET scan. Consistent with our hypothesis, neuroticism was positively correlated with PFC FAAH binding (r = 0.42, p = 0.021), controlling for genotype. Neuroticism was also positively correlated with dorsal putamen FAAH binding (r = 0.53, p = 0.0024), controlling for genotype. Elevated brain FAAH is an endophenotype for high neuroticism in BPD and ASPD. Novel pharmacological therapeutics that inhibit FAAH could emerge as potential new treatments for BPD and ASPD with high neuroticism. |
format | Online Article Text |
id | pubmed-8782862 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-87828622022-01-24 Higher trait neuroticism is associated with greater fatty acid amide hydrolase binding in borderline and antisocial personality disorders Kolla, Nathan J. Boileau, Isabelle Bagby, R. Michael Sci Rep Article Borderline personality disorder (BPD) and antisocial personality disorder (ASPD) are the two most frequently diagnosed and researched DSM-5 personality disorders, and both are characterized by high levels of trait neuroticism. Fatty acid amide hydrolase (FAAH), an enzyme of the endocannabinoid system (ECS), has been linked to regulation of mood through modulation of anandamide, an endocannabinoid. We hypothesized that prefrontal cortex (PFC) FAAH binding would relate to trait neuroticism in personality disorders. Thirty-one individuals with personality disorders (20 with BPD and 11 with ASPD) completed the investigation. All participants completed the revised NEO Personality Inventory, which yields standardized scores (e.g., T scores) for the traits of neuroticism, openness, conscientiousness, agreeableness, and extraversion. All participants were medication free and were not utilizing illicit substances as determined by drug urinalysis. Additionally, none of the participants had a comorbid major depressive episode, bipolar disorder, psychotic disorder, or substance use disorder. Each participant underwent one [(11)C]CURB PET scan. Consistent with our hypothesis, neuroticism was positively correlated with PFC FAAH binding (r = 0.42, p = 0.021), controlling for genotype. Neuroticism was also positively correlated with dorsal putamen FAAH binding (r = 0.53, p = 0.0024), controlling for genotype. Elevated brain FAAH is an endophenotype for high neuroticism in BPD and ASPD. Novel pharmacological therapeutics that inhibit FAAH could emerge as potential new treatments for BPD and ASPD with high neuroticism. Nature Publishing Group UK 2022-01-21 /pmc/articles/PMC8782862/ /pubmed/35064143 http://dx.doi.org/10.1038/s41598-022-04789-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Kolla, Nathan J. Boileau, Isabelle Bagby, R. Michael Higher trait neuroticism is associated with greater fatty acid amide hydrolase binding in borderline and antisocial personality disorders |
title | Higher trait neuroticism is associated with greater fatty acid amide hydrolase binding in borderline and antisocial personality disorders |
title_full | Higher trait neuroticism is associated with greater fatty acid amide hydrolase binding in borderline and antisocial personality disorders |
title_fullStr | Higher trait neuroticism is associated with greater fatty acid amide hydrolase binding in borderline and antisocial personality disorders |
title_full_unstemmed | Higher trait neuroticism is associated with greater fatty acid amide hydrolase binding in borderline and antisocial personality disorders |
title_short | Higher trait neuroticism is associated with greater fatty acid amide hydrolase binding in borderline and antisocial personality disorders |
title_sort | higher trait neuroticism is associated with greater fatty acid amide hydrolase binding in borderline and antisocial personality disorders |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782862/ https://www.ncbi.nlm.nih.gov/pubmed/35064143 http://dx.doi.org/10.1038/s41598-022-04789-9 |
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