The combined DNA and RNA synthetic capabilities of archaeal DNA primase facilitate primer hand-off to the replicative DNA polymerase

Replicative DNA polymerases cannot initiate DNA synthesis de novo and rely on dedicated RNA polymerases, primases, to generate a short primer. This primer is then extended by the DNA polymerase. In diverse archaeal species, the primase has long been known to have the ability to synthesize both RNA a...

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Detalles Bibliográficos
Autores principales: Greci, Mark D., Dooher, Joseph D., Bell, Stephen D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782868/
https://www.ncbi.nlm.nih.gov/pubmed/35064114
http://dx.doi.org/10.1038/s41467-022-28093-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782868/
https://www.ncbi.nlm.nih.gov/pubmed/35064114
http://dx.doi.org/10.1038/s41467-022-28093-2

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