A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-β signaling

Loss of Klotho, an anti-aging protein, plays a critical role in the pathogenesis of chronic kidney diseases. As Klotho is a large transmembrane protein, it is challenging to harness it as a therapeutic remedy. Here we report the discovery of a Klotho-derived peptide 1 (KP1) protecting kidneys by tar...

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Detalles Bibliográficos
Autores principales: Yuan, Qian, Ren, Qian, Li, Li, Tan, Huishi, Lu, Meizhi, Tian, Yuan, Huang, Lu, Zhao, Boxin, Fu, Haiyan, Hou, Fan Fan, Zhou, Lili, Liu, Youhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782923/
https://www.ncbi.nlm.nih.gov/pubmed/35064106
http://dx.doi.org/10.1038/s41467-022-28096-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782923/
https://www.ncbi.nlm.nih.gov/pubmed/35064106
http://dx.doi.org/10.1038/s41467-022-28096-z

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