TM6SF2/PNPLA3/MBOAT7 Loss-of-Function Genetic Variants Impact on NAFLD Development and Progression Both in Patients and in In Vitro Models

BACKGROUND & AIMS: The I148M Patatin-like Phospholipase Domain-containing 3 (PNPLA3), the rs641738 in the Membrane bound O-acyltransferase domain containing 7-transmembrane channel-like 4 (MBOAT7-TMC4) locus, and the E167K Transmembrane 6 Superfamily Member 2 (TM6SF2) polymorphisms represent the...

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Detalles Bibliográficos
Autores principales: Longo, Miriam, Meroni, Marica, Paolini, Erika, Erconi, Veronica, Carli, Fabrizia, Fortunato, Francesco, Ronchi, Dario, Piciotti, Roberto, Sabatini, Silvia, Macchi, Chiara, Alisi, Anna, Miele, Luca, Soardo, Giorgio, Comi, Giacomo Pietro, Valenti, Luca, Ruscica, Massimiliano, Fracanzani, Anna L., Gastaldelli, Amalia, Dongiovanni, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783129/
https://www.ncbi.nlm.nih.gov/pubmed/34823063
http://dx.doi.org/10.1016/j.jcmgh.2021.11.007

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