TNFα Induces LGR5+ Stem Cell Dysfunction In Patients With Crohn’s Disease

BACKGROUND & AIMS: Tumor necrosis factor alpha (TNFα) is considered a major tissue damage-promoting effector in Crohn’s disease (CD) pathogenesis. Patient-derived intestinal organoid (enteroid) recapitulates the disease-specific characteristics of the intestinal epithelium. This study aimed to e...

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Detalles Bibliográficos
Autores principales: Lee, Chansu, An, Minae, Joung, Je-Gun, Park, Woong-Yang, Chang, Dong Kyung, Kim, Young-Ho, Hong, Sung Noh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783132/
https://www.ncbi.nlm.nih.gov/pubmed/34700029
http://dx.doi.org/10.1016/j.jcmgh.2021.10.010

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