Cargando…

A recombinant SARS-CoV-2 receptor-binding domain expressed in an engineered fungal strain of Thermothelomyces heterothallica induces a functional immune response in mice

Since the beginning of the COVID-19 pandemic, the development of effective vaccines against this pathogen has been a priority for the scientific community. Several strategies have been developed including vaccines based on recombinant viral protein fragments. The receptor-binding domain (RBD) in the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lazo, Laura, Bequet-Romero, Monica, Lemos, Gilda, Musacchio, Alexis, Cabrales, Ania, Bruno, Andy J., Ariel Espinosa, Luis, Saloheimo, Markku, Vitikainen, Marika, Hernández, Amalia, Emalfarb, Mark, Tchelet, Ronen, Suzarte, Edith, Guillén, Gerardo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Ltd. 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783260/ https://www.ncbi.nlm.nih.gov/pubmed/35078661 http://dx.doi.org/10.1016/j.vaccine.2022.01.007

Ejemplares similares

The Highly Productive Thermothelomyces heterothallica C1 Expression System as a Host for Rapid Development of Influenza Vaccines
por: Keresztes, Gabor, et al.
Publicado: (2022)

Toxicity and Local Tolerance of a Novel Spike Protein RBD Vaccine Against SARS-CoV-2, Produced Using the C1 Thermothelomyces Heterothallica Protein Expression Platform
por: Ramot, Yuval, et al.
Publicado: (2022)

Preclinical immunogenicity and protective efficacy of a SARS-CoV-2 RBD-based vaccine produced with the thermophilic filamentous fungal expression system Thermothelomyces heterothallica C1
por: Gonzalez-Hernandez, Mariana, et al.
Publicado: (2023)

Development of a Modular Vaccine Platform for Multimeric Antigen Display Using an Orthobunyavirus Model
por: Aebischer, Andrea, et al.
Publicado: (2021)

Thermophilic Filamentous Fungus C1-Cell-Cloned SARS-CoV-2-Spike-RBD-Subunit-Vaccine Adjuvanted with Aldydrogel(®)85 Protects K18-hACE2 Mice against Lethal Virus Challenge
por: Nechooshtan, Ram, et al.
Publicado: (2022)

Array comparative genomic hybridization analysis of Trichoderma reesei strains with enhanced cellulase production properties
por: Vitikainen, Marika, et al.
Publicado: (2010)

Engineered Fungus Thermothelomyces thermophilus Producing Plant Storage Proteins
por: Balabanova, Larissa, et al.
Publicado: (2022)

Sexual crossing of thermophilic fungus Myceliophthora heterothallica improved enzymatic degradation of sugar beet pulp
por: Aguilar-Pontes, Maria Victoria, et al.
Publicado: (2016)

In-solution buffer-free digestion allows full-sequence coverage and complete characterization of post-translational modifications of the receptor-binding domain of SARS-CoV-2 in a single ESI–MS spectrum
por: Espinosa, Luis Ariel, et al.
Publicado: (2021)

Chimeric Antigen by the Fusion of SARS-CoV-2 Receptor Binding Domain with the Extracellular Domain of Human CD154: A Promising Improved Vaccine Candidate
por: Ávalos, Ileanet, et al.
Publicado: (2022)

Screening of candidate regulators for cellulase and hemicellulase production in Trichoderma reesei and identification of a factor essential for cellulase production
por: Häkkinen, Mari, et al.
Publicado: (2014)

Optimization of Transesterification Reactions with CLEA-Immobilized Feruloyl Esterases from Thermothelomyces thermophila and Talaromyces wortmannii
por: Zerva, Anastasia, et al.
Publicado: (2018)

Identification of Thermostable Xylose Reductase from Thermothelomyces thermophilus: A Biochemical Characterization Approach to Meet Biofuel Challenges
por: Ali, Nabeel, et al.
Publicado: (2022)

Characterization of a novel AA3_1 xylooligosaccharide dehydrogenase from Thermothelomyces myriococcoides CBS 398.93
por: Zhao, Hongbo, et al.
Publicado: (2022)

Safety evaluation of a β-mannanase enzyme preparation produced with Thermothelomyces thermophilus expressing a protein-engineered β-mannanase gene
por: Kern, Andreas, et al.
Publicado: (2020)

Structure–function studies of a novel laccase-like multicopper oxidase from Thermothelomyces thermophila provide insights into its biological role
por: Kosinas, Christos, et al.
Publicado: (2023)

Transcriptomic insights into the roles of the transcription factors Clr1, Clr2 and Clr4 in lignocellulose degradation of the thermophilic fungal platform Thermothelomyces thermophilus
por: Siebecker, Benedikt, et al.
Publicado: (2023)

The tetravalent formulation of domain III-capsid proteins recalls memory B- and T-cell responses induced in monkeys by an experimental dengue virus infection
por: Gil, Lázaro, et al.
Publicado: (2017)

Effect of pH, Temperature, and Chemicals on the Endoglucanases and β-Glucosidases from the Thermophilic Fungus Myceliophthora heterothallica F.2.1.4. Obtained by Solid-State and Submerged Cultivation
por: Teixeira da Silva, Vanessa de Cássia, et al.
Publicado: (2016)

An engineered SARS-CoV-2 receptor-binding domain produced in Pichia pastoris as a candidate vaccine antigen
por: Limonta-Fernández, Miladys, et al.
Publicado: (2022)

Screening for immune response against Dengue virus in Vietnamese non-human primates: implications for vaccine developers
por: Lazo Vázquez, Laura, et al.
Publicado: (2017)

Secreted fungal sulfhydryl oxidases: sequence analysis and characterisation of a representative flavin-dependent enzyme from Aspergillus oryzae
por: Faccio, Greta, et al.
Publicado: (2010)

Comparison of intracellular and secretion-based strategies for production of human α-galactosidase A in the filamentous fungus Trichoderma reesei
por: Smith, Wesley, et al.
Publicado: (2014)

The effects of disruption of phosphoglucose isomerase gene on carbon utilisation and cellulase production in Trichoderma reesei Rut-C30
por: Limón, M Carmen, et al.
Publicado: (2011)

The effects of extracellular pH and of the transcriptional regulator PACI on the transcriptome of Trichoderma reesei
por: Häkkinen, Mari, et al.
Publicado: (2015)

Transcriptional monitoring of steady state and effects of anaerobic phases in chemostat cultures of the filamentous fungus Trichoderma reesei
por: Rautio, Jari J, et al.
Publicado: (2006)

(13)C-metabolic flux ratio and novel carbon path analyses confirmed that Trichoderma reesei uses primarily the respirative pathway also on the preferred carbon source glucose
por: Jouhten, Paula, et al.
Publicado: (2009)

A new crystal form of Aspergillus oryzae catechol oxidase and evaluation of copper site structures in coupled binuclear copper enzymes
por: Penttinen, Leena, et al.
Publicado: (2018)

Physiological evaluation of the filamentous fungus Trichoderma reesei in production processes by marker gene expression analysis
por: Rautio, Jari J, et al.
Publicado: (2007)

Novel genetic tools that enable highly pure protein production in Trichoderma reesei
por: Rantasalo, Anssi, et al.
Publicado: (2019)

Deep learning for numerical applications with SAS
por: Bequet, Henry
Publicado: (2018)

Trois bibliothèques européennes face à Google: à l'origine de la bibliothèque numérique (1990-2010)
por: Béquet, Gaëlle
Publicado: (2015)

Comparison of protein coding gene contents of the fungal phyla Pezizomycotina and Saccharomycotina
por: Arvas, Mikko, et al.
Publicado: (2007)

Exploring laccase-like multicopper oxidase genes from the ascomycete Trichoderma reesei: a functional, phylogenetic and evolutionary study
por: Levasseur, Anthony, et al.
Publicado: (2010)

Can Complementary Prime-Boost Immunization Strategies Be an Alternative and Promising Vaccine Approach Against Dengue Virus?
por: Valdés, Iris, et al.
Publicado: (2019)

Expression, purification and characterization of a recombinant fusion protein based on the human papillomavirus-16 E7 antigen
por: Granadillo, Milaid, et al.
Publicado: (2013)

Re-annotation of the CAZy genes of Trichoderma reesei and transcription in the presence of lignocellulosic substrates
por: Häkkinen, Mari, et al.
Publicado: (2012)

Safety and efficacy of a feed additive consisting of endo‐1,4‐β‐ d‐mannanase produced by Thermothelomyces thermophilus DSM 33149 (Natupulse® TS/TS L) for chickens and turkeys for fattening, minor poultry species for fattening and ornamental birds (BASF SE)
por: Bampidis, Vasileios, et al.
Publicado: (2023)

Common features and interesting differences in transcriptional responses to secretion stress in the fungi Trichoderma reesei and Saccharomyces cerevisiae
por: Arvas, Mikko, et al.
Publicado: (2006)

Monitoring of transcriptional regulation in Pichia pastoris under protein production conditions
por: Gasser, Brigitte, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_i8lkcqpcbqd76fkcdv4pgq3u9i