Targeting PARP proteins in acute leukemia: DNA damage response inhibition and therapeutic strategies

The members of the Poly(ADP‐ribose) polymerase (PARP) superfamily are involved in several biological processes and, in particular, in the DNA damage response (DDR). The most studied members, PARP1, PARP2 and PARP3, act as sensors of DNA damages, in order to activate different intracellular repair pa...

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Detalles Bibliográficos
Autores principales: Padella, Antonella, Ghelli Luserna Di Rorà, Andrea, Marconi, Giovanni, Ghetti, Martina, Martinelli, Giovanni, Simonetti, Giorgia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783444/
https://www.ncbi.nlm.nih.gov/pubmed/35065680
http://dx.doi.org/10.1186/s13045-022-01228-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783444/
https://www.ncbi.nlm.nih.gov/pubmed/35065680
http://dx.doi.org/10.1186/s13045-022-01228-0

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