tRF3008A suppresses the progression and metastasis of colorectal cancer by destabilizing FOXK1 in an AGO-dependent manner

BACKGROUND: tRNA-derived fragments (tRFs) have been shown to have critical regulatory roles in cancer biology. However, the contributions of tRFs to colorectal cancer (CRC) remain largely unknown. METHODS: tRF3008A (a tRFRNA derived from tRNA(Val)) was identified by RNA sequencing and validated by q...

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Detalles Bibliográficos
Autores principales: Han, Ying, Peng, Yinghui, Liu, Shanshan, Wang, Xinwen, Cai, Changjing, Guo, Cao, Chen, Yihong, Gao, Le, Huang, Qiaoqiao, He, Min, Shen, Edward, Long, Jie, Yu, Jian, Shen, Hong, Zeng, Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783529/
https://www.ncbi.nlm.nih.gov/pubmed/35065674
http://dx.doi.org/10.1186/s13046-021-02190-4

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