Associations Between Vancomycin Exposure and Acute Kidney Injury Within the Recommended Area Under the Curve Therapeutic Exposure Range Among Patients With Methicillin-Resistant Staphylococcus aureus Bloodstream Infections

Among patients with methicillin-resistant Staphylococcus aureus bacteremia, vancomycin-associated acute kidney injury increased as a function of the day 2 area under the curve (AUC), even for daily AUCs within the recommended therapeutic range (400–600). Further data are needed to determine if daily...

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Autores principales: Lodise, Thomas P, Scheetz, Marc, Carreno, Joseph J, Chambers, Henry, Fowler, Vance, Holland, Thomas L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783632/
https://www.ncbi.nlm.nih.gov/pubmed/35079599
http://dx.doi.org/10.1093/ofid/ofab651
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author Lodise, Thomas P
Scheetz, Marc
Carreno, Joseph J
Chambers, Henry
Fowler, Vance
Holland, Thomas L
author_facet Lodise, Thomas P
Scheetz, Marc
Carreno, Joseph J
Chambers, Henry
Fowler, Vance
Holland, Thomas L
author_sort Lodise, Thomas P
collection PubMed
description Among patients with methicillin-resistant Staphylococcus aureus bacteremia, vancomycin-associated acute kidney injury increased as a function of the day 2 area under the curve (AUC), even for daily AUCs within the recommended therapeutic range (400–600). Further data are needed to determine if daily AUCs <400 can be maintained without compromising efficacy.
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spelling pubmed-87836322022-01-24 Associations Between Vancomycin Exposure and Acute Kidney Injury Within the Recommended Area Under the Curve Therapeutic Exposure Range Among Patients With Methicillin-Resistant Staphylococcus aureus Bloodstream Infections Lodise, Thomas P Scheetz, Marc Carreno, Joseph J Chambers, Henry Fowler, Vance Holland, Thomas L Open Forum Infect Dis Brief Report Among patients with methicillin-resistant Staphylococcus aureus bacteremia, vancomycin-associated acute kidney injury increased as a function of the day 2 area under the curve (AUC), even for daily AUCs within the recommended therapeutic range (400–600). Further data are needed to determine if daily AUCs <400 can be maintained without compromising efficacy. Oxford University Press 2022-01-22 /pmc/articles/PMC8783632/ /pubmed/35079599 http://dx.doi.org/10.1093/ofid/ofab651 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Lodise, Thomas P
Scheetz, Marc
Carreno, Joseph J
Chambers, Henry
Fowler, Vance
Holland, Thomas L
Associations Between Vancomycin Exposure and Acute Kidney Injury Within the Recommended Area Under the Curve Therapeutic Exposure Range Among Patients With Methicillin-Resistant Staphylococcus aureus Bloodstream Infections
title Associations Between Vancomycin Exposure and Acute Kidney Injury Within the Recommended Area Under the Curve Therapeutic Exposure Range Among Patients With Methicillin-Resistant Staphylococcus aureus Bloodstream Infections
title_full Associations Between Vancomycin Exposure and Acute Kidney Injury Within the Recommended Area Under the Curve Therapeutic Exposure Range Among Patients With Methicillin-Resistant Staphylococcus aureus Bloodstream Infections
title_fullStr Associations Between Vancomycin Exposure and Acute Kidney Injury Within the Recommended Area Under the Curve Therapeutic Exposure Range Among Patients With Methicillin-Resistant Staphylococcus aureus Bloodstream Infections
title_full_unstemmed Associations Between Vancomycin Exposure and Acute Kidney Injury Within the Recommended Area Under the Curve Therapeutic Exposure Range Among Patients With Methicillin-Resistant Staphylococcus aureus Bloodstream Infections
title_short Associations Between Vancomycin Exposure and Acute Kidney Injury Within the Recommended Area Under the Curve Therapeutic Exposure Range Among Patients With Methicillin-Resistant Staphylococcus aureus Bloodstream Infections
title_sort associations between vancomycin exposure and acute kidney injury within the recommended area under the curve therapeutic exposure range among patients with methicillin-resistant staphylococcus aureus bloodstream infections
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783632/
https://www.ncbi.nlm.nih.gov/pubmed/35079599
http://dx.doi.org/10.1093/ofid/ofab651
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