Metabolic reprogramming during hyperammonemia targets mitochondrial function and postmitotic senescence

Ammonia is a cytotoxic metabolite with pleiotropic molecular and metabolic effects, including senescence induction. During dysregulated ammonia metabolism, which occurs in chronic diseases, skeletal muscle becomes a major organ for nonhepatocyte ammonia uptake. Muscle ammonia disposal occurs in mito...

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Detalles Bibliográficos
Autores principales: Kumar, Avinash, Welch, Nicole, Mishra, Saurabh, Bellar, Annette, Silva, Rafaella Nasciemento, Li, Ling, Singh, Shashi Shekhar, Sharkoff, Mary, Kerr, Alexis, Chelluboyina, Aruna Kumar, Sekar, Jinendiran, Attaway, Amy H., Hoppel, Charles, Willard, Belinda, Davuluri, Gangarao, Dasarathy, Srinivasan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783680/
https://www.ncbi.nlm.nih.gov/pubmed/34935641
http://dx.doi.org/10.1172/jci.insight.154089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783680/
https://www.ncbi.nlm.nih.gov/pubmed/34935641
http://dx.doi.org/10.1172/jci.insight.154089

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