Hypoxia induces DOT1L in articular cartilage to protect against osteoarthritis

Osteoarthritis is the most prevalent joint disease worldwide, and it is a leading source of pain and disability. To date, this disease lacks curative treatment, as underlying molecular mechanisms remain largely unknown. The histone methyltransferase DOT1L protects against osteoarthritis, and DOT1L-m...

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Detalles Bibliográficos
Autores principales: De Roover, Astrid, Núñez, Ana Escribano, Cornelis, Frederique M.F., Cherifi, Chahrazad, Casas-Fraile, Leire, Sermon, An, Cailotto, Frederic, Lories, Rik J., Monteagudo, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783684/
https://www.ncbi.nlm.nih.gov/pubmed/34727094
http://dx.doi.org/10.1172/jci.insight.150451

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