T cell–derived tumor necrosis factor induces cytotoxicity by activating RIPK1-dependent target cell death

TNF ligation of TNF receptor 1 (TNFR1) promotes either inflammation and cell survival by (a) inhibiting RIPK1’s death-signaling function and activating NF-κB or (b) causing RIPK1 to associate with the death-inducing signaling complex to initiate apoptosis or necroptosis. The cellular source of TNF t...

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Detalles Bibliográficos
Autores principales: Chun, Nicholas, Ang, Rosalind L., Chan, Mark, Fairchild, Robert L., Baldwin, William M., Horwitz, Julian K., Gelles, Jesse D., Chipuk, Jerry Edward, Kelliher, Michelle A., Pavlov, Vasile I., Li, Yansui, Homann, Dirk, Heeger, Peter S., Ting, Adrian T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783689/
https://www.ncbi.nlm.nih.gov/pubmed/34752416
http://dx.doi.org/10.1172/jci.insight.148643

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783689/
https://www.ncbi.nlm.nih.gov/pubmed/34752416
http://dx.doi.org/10.1172/jci.insight.148643

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