Muscle fibrosis and maladaptation occur progressively in CKD and are rescued by dialysis

BACKGROUND: Skeletal muscle maladaptation accompanies chronic kidney disease (CKD) and negatively affects physical function. Emphasis in CKD has historically been placed on muscle fiber–intrinsic deficits, such as altered protein metabolism and atrophy. However, targeted treatment of fiber-intrinsic...

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Detalles Bibliográficos
Autores principales: Brightwell, Camille R., Kulkarni, Ameya S., Paredes, William, Zhang, Kehao, Perkins, Jaclyn B., Gatlin, Knubian J., Custodio, Matthew, Farooq, Hina, Zaidi, Bushra, Pai, Rima, Buttar, Rupinder S., Tang, Yan, Melamed, Michal L., Hostetter, Thomas H., Pessin, Jeffrey E., Hawkins, Meredith, Fry, Christopher S., Abramowitz, Matthew K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Clinical Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783691/
https://www.ncbi.nlm.nih.gov/pubmed/34784301
http://dx.doi.org/10.1172/jci.insight.150112

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