Electrophysiological measures from human iPSC-derived neurons are associated with schizophrenia clinical status and predict individual cognitive performance

Neurons derived from human induced pluripotent stem cells (hiPSCs) have been used to model basic cellular aspects of neuropsychiatric disorders, but the relationship between the emergent phenotypes and the clinical characteristics of donor individuals has been unclear. We analyzed RNA expression and...

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Detalles Bibliográficos
Autores principales: Page, Stephanie Cerceo, Sripathy, Srinidhi Rao, Farinelli, Federica, Ye, Zengyou, Wang, Yanhong, Hiler, Daniel J., Pattie, Elizabeth A., Nguyen, Claudia V., Tippani, Madhavi, Moses, Rebecca L., Chen, Huei-Ying, Tran, Matthew Nguyen, Eagles, Nicholas J., Stolz, Joshua M., Catallini, Joseph L., Soudry, Olivia R., Dickinson, Dwight, Berman, Karen F., Apud, Jose A., Weinberger, Daniel R., Martinowich, Keri, Jaffe, Andrew E., Straub, Richard E., Maher, Brady J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784142/
https://www.ncbi.nlm.nih.gov/pubmed/35017298
http://dx.doi.org/10.1073/pnas.2109395119

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