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Role of helical structure and dynamics in oligoadenylate synthetase 1 (OAS1) mismatch tolerance and activation by short dsRNAs

The 2’-5’-oligoadenylate synthetases (OAS) are innate immune sensors of cytosolic double-stranded RNA (dsRNA) that play a critical role in limiting viral infection. How these proteins are able to avoid aberrant activation by cellular RNAs is not fully understood, but adenosine-to-inosine (A-to-I) ed...

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Detalles Bibliográficos
Autores principales:	Schwartz, Samantha L., Dey, Debayan, Tanquary, Julia, Bair, Camden R., Lowen, Anice C., Conn, Graeme L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784149/ https://www.ncbi.nlm.nih.gov/pubmed/35017296 http://dx.doi.org/10.1073/pnas.2107111119

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