Inhibition of EZH2 transactivation function sensitizes solid tumors to genotoxic stress

Drugs that block the activity of the methyltransferase EZH2 are in clinical development for the treatment of non-Hodgkin lymphomas harboring EZH2 gain-of-function mutations that enhance its polycomb repressive function. We have previously reported that EZH2 can act as a transcriptional activator in...

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Detalles Bibliográficos
Autores principales: Liao, Yiji, Chen, Chen-Hao, Xiao, Tengfei, de la Peña Avalos, Bárbara, Dray, Eloise V., Cai, Changmeng, Gao, Shuai, Shah, Neel, Zhang, Zhao, Feit, Avery, Xue, Pengya, Liu, Zhijie, Yang, Mei, Lee, Ji Hoon, Xu, Han, Li, Wei, Mei, Shenglin, Pierre, Roodolph S., Shu, Shaokun, Fei, Teng, Duarte, Melissa, Zhao, Jin, Bradner, James E., Polyak, Kornelia, Kantoff, Philip W., Long, Henry, Balk, Steven P., Liu, X. Shirley, Brown, Myles, Xu, Kexin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784159/
https://www.ncbi.nlm.nih.gov/pubmed/35031563
http://dx.doi.org/10.1073/pnas.2105898119

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