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Protocatechuic acid protects mice from influenza A virus infection
Influenza A virus (IAV) H1N1 infection remains great challenge to public health and causes great burden over the world. Although there are anti-viral agents available, searching for effective agents to treat H1N1 infection is still in urgent because of the emergence of resistant strain. Protocatechu...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784203/ https://www.ncbi.nlm.nih.gov/pubmed/35067799 http://dx.doi.org/10.1007/s10096-022-04401-y |
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author | Wang, Qian Ren, Xiaojuan Wu, Jinhua Li, Hongrong Yang, Liu Zhang, Yan Wang, Xin Li, Zhicun |
author_facet | Wang, Qian Ren, Xiaojuan Wu, Jinhua Li, Hongrong Yang, Liu Zhang, Yan Wang, Xin Li, Zhicun |
author_sort | Wang, Qian |
collection | PubMed |
description | Influenza A virus (IAV) H1N1 infection remains great challenge to public health and causes great burden over the world. Although there are anti-viral agents available, searching for effective agents to treat H1N1 infection is still in urgent because of the emergence of resistant strain. Protocatechuic acid (PCA) is a biological agent with multiple functions. In present study, we explored the effects of PCA on H1N1 infection. Mice infected with mouse adapted influenza strain A/Font Monmouth were administrated with PCA. The body weight change, mortality, lung index, viral titer, immune cell infiltration, and cytokine production in the lung were monitored. The activation of toll-like receptor 4 (TLR4) and nuclear factor kappa light chain enhancer of activated B cells (NF-κB) pathway was investigated. PCA treatment prevented H1N1 infection-induced mice body weight loss and death. PCA reduced the lung index, viral titer, infiltration of immune cells, and cytokine level in the lung, as well as suppressed H1N1-induced TLR4/NF-κB activation. PCA protects mice against H1N1 infection and could be a potential therapeutic agent to treat influenza. |
format | Online Article Text |
id | pubmed-8784203 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-87842032022-01-24 Protocatechuic acid protects mice from influenza A virus infection Wang, Qian Ren, Xiaojuan Wu, Jinhua Li, Hongrong Yang, Liu Zhang, Yan Wang, Xin Li, Zhicun Eur J Clin Microbiol Infect Dis Original Article Influenza A virus (IAV) H1N1 infection remains great challenge to public health and causes great burden over the world. Although there are anti-viral agents available, searching for effective agents to treat H1N1 infection is still in urgent because of the emergence of resistant strain. Protocatechuic acid (PCA) is a biological agent with multiple functions. In present study, we explored the effects of PCA on H1N1 infection. Mice infected with mouse adapted influenza strain A/Font Monmouth were administrated with PCA. The body weight change, mortality, lung index, viral titer, immune cell infiltration, and cytokine production in the lung were monitored. The activation of toll-like receptor 4 (TLR4) and nuclear factor kappa light chain enhancer of activated B cells (NF-κB) pathway was investigated. PCA treatment prevented H1N1 infection-induced mice body weight loss and death. PCA reduced the lung index, viral titer, infiltration of immune cells, and cytokine level in the lung, as well as suppressed H1N1-induced TLR4/NF-κB activation. PCA protects mice against H1N1 infection and could be a potential therapeutic agent to treat influenza. Springer Berlin Heidelberg 2022-01-24 2022 /pmc/articles/PMC8784203/ /pubmed/35067799 http://dx.doi.org/10.1007/s10096-022-04401-y Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Original Article Wang, Qian Ren, Xiaojuan Wu, Jinhua Li, Hongrong Yang, Liu Zhang, Yan Wang, Xin Li, Zhicun Protocatechuic acid protects mice from influenza A virus infection |
title | Protocatechuic acid protects mice from influenza A virus infection |
title_full | Protocatechuic acid protects mice from influenza A virus infection |
title_fullStr | Protocatechuic acid protects mice from influenza A virus infection |
title_full_unstemmed | Protocatechuic acid protects mice from influenza A virus infection |
title_short | Protocatechuic acid protects mice from influenza A virus infection |
title_sort | protocatechuic acid protects mice from influenza a virus infection |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784203/ https://www.ncbi.nlm.nih.gov/pubmed/35067799 http://dx.doi.org/10.1007/s10096-022-04401-y |
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