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Signaling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1α in lipopolysaccharide-activated macrophages

Activated macrophages undergo metabolic reprogramming, which not only supports their energetic demands but also allows for the production of specific metabolites that function as signaling molecules. Several Krebs cycles, or Krebs-cycle-derived metabolites, including succinate, α-ketoglutarate, and...

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Detalles Bibliográficos
Autores principales:	Williams, Niamh C., Ryan, Dylan G., Costa, Ana S.H., Mills, Evanna L., Jedrychowski, Mark P., Cloonan, Suzanne M., Frezza, Christian, O'Neill, Luke A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784330/ https://www.ncbi.nlm.nih.gov/pubmed/34929172 http://dx.doi.org/10.1016/j.jbc.2021.101501

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