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Association Between Prediabetes and Erectile Dysfunction: A Meta-Analysis

BACKGROUND: Diabetes has been associated with the increased risk of erectile dysfunction (ED). However, previous studies evaluating the association between prediabetes and ED showed inconsistent results. We performed a meta-analysis of observational studies to systematically evaluate the above assoc...

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Autores principales: Jin, Mingyu, Yuan, Shaoying, Wang, Bo, Yi, Luqi, Wang, Chenxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784376/
https://www.ncbi.nlm.nih.gov/pubmed/35082752
http://dx.doi.org/10.3389/fendo.2021.733434
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author Jin, Mingyu
Yuan, Shaoying
Wang, Bo
Yi, Luqi
Wang, Chenxia
author_facet Jin, Mingyu
Yuan, Shaoying
Wang, Bo
Yi, Luqi
Wang, Chenxia
author_sort Jin, Mingyu
collection PubMed
description BACKGROUND: Diabetes has been associated with the increased risk of erectile dysfunction (ED). However, previous studies evaluating the association between prediabetes and ED showed inconsistent results. We performed a meta-analysis of observational studies to systematically evaluate the above association. METHODS: Relevant observational studies were retrieved by search of PubMed, Embase, and Web of Science databases. A random-effect model which incorporated the potential intra-study heterogeneity was used for the meta-analysis. Subgroup analyses were performed to evaluate the influences of study characteristics on the outcome. RESULTS: Nine studies (five matched case-control studies and four cross-sectional studies) were included. Age were adjusted or matched in all of the studies. Pooled results showed that compared to men with normoglycemia, men with prediabetes were associated with higher prevalence of ED (odds ratio = 1.62, 95% confidence interval: 1.28 to 2.07, P < 0.001; I(2) = 78%). Subgroup analyses showed that the association was not significantly affected by definition of prediabetes, diagnostic tool for ED, or controlling of additional variables besides age (both P for subgroup difference > 0.05). However, the association between prediabetes and ED seemed to be stronger in case-control studies than that in cross-sectional studies, and in studies with younger men (mean age < 50 years) than in those with older men (mean age ≥ 50 years; both P for subgroup difference < 0.05). CONCLUSIONS: Prediabetes is associated with higher prevalence of ED, which may be independent of age of the males and may be stronger in young men.
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spelling pubmed-87843762022-01-25 Association Between Prediabetes and Erectile Dysfunction: A Meta-Analysis Jin, Mingyu Yuan, Shaoying Wang, Bo Yi, Luqi Wang, Chenxia Front Endocrinol (Lausanne) Endocrinology BACKGROUND: Diabetes has been associated with the increased risk of erectile dysfunction (ED). However, previous studies evaluating the association between prediabetes and ED showed inconsistent results. We performed a meta-analysis of observational studies to systematically evaluate the above association. METHODS: Relevant observational studies were retrieved by search of PubMed, Embase, and Web of Science databases. A random-effect model which incorporated the potential intra-study heterogeneity was used for the meta-analysis. Subgroup analyses were performed to evaluate the influences of study characteristics on the outcome. RESULTS: Nine studies (five matched case-control studies and four cross-sectional studies) were included. Age were adjusted or matched in all of the studies. Pooled results showed that compared to men with normoglycemia, men with prediabetes were associated with higher prevalence of ED (odds ratio = 1.62, 95% confidence interval: 1.28 to 2.07, P < 0.001; I(2) = 78%). Subgroup analyses showed that the association was not significantly affected by definition of prediabetes, diagnostic tool for ED, or controlling of additional variables besides age (both P for subgroup difference > 0.05). However, the association between prediabetes and ED seemed to be stronger in case-control studies than that in cross-sectional studies, and in studies with younger men (mean age < 50 years) than in those with older men (mean age ≥ 50 years; both P for subgroup difference < 0.05). CONCLUSIONS: Prediabetes is associated with higher prevalence of ED, which may be independent of age of the males and may be stronger in young men. Frontiers Media S.A. 2022-01-10 /pmc/articles/PMC8784376/ /pubmed/35082752 http://dx.doi.org/10.3389/fendo.2021.733434 Text en Copyright © 2022 Jin, Yuan, Wang, Yi and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Jin, Mingyu
Yuan, Shaoying
Wang, Bo
Yi, Luqi
Wang, Chenxia
Association Between Prediabetes and Erectile Dysfunction: A Meta-Analysis
title Association Between Prediabetes and Erectile Dysfunction: A Meta-Analysis
title_full Association Between Prediabetes and Erectile Dysfunction: A Meta-Analysis
title_fullStr Association Between Prediabetes and Erectile Dysfunction: A Meta-Analysis
title_full_unstemmed Association Between Prediabetes and Erectile Dysfunction: A Meta-Analysis
title_short Association Between Prediabetes and Erectile Dysfunction: A Meta-Analysis
title_sort association between prediabetes and erectile dysfunction: a meta-analysis
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784376/
https://www.ncbi.nlm.nih.gov/pubmed/35082752
http://dx.doi.org/10.3389/fendo.2021.733434
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