Recombinant Adenoviruses for Delivery of Therapeutics Following Spinal Cord Injury

The regeneration of nerve tissue after spinal cord injury is a complex and poorly understood process. Medication and surgery are not very effective treatments for patients with spinal cord injuries. Gene therapy is a popular approach for the treatment of such patients. The delivery of therapeutic ge...

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Autores principales: Sosnovtseva, Anastasiia O., Stepanova, Olga V., Stepanenko, Aleksei A., Voronova, Anastasia D., Chadin, Andrey V., Valikhov, Marat P., Chekhonin, Vladimir P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784517/
https://www.ncbi.nlm.nih.gov/pubmed/35082666
http://dx.doi.org/10.3389/fphar.2021.777628
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author Sosnovtseva, Anastasiia O.
Stepanova, Olga V.
Stepanenko, Aleksei A.
Voronova, Anastasia D.
Chadin, Andrey V.
Valikhov, Marat P.
Chekhonin, Vladimir P.
author_facet Sosnovtseva, Anastasiia O.
Stepanova, Olga V.
Stepanenko, Aleksei A.
Voronova, Anastasia D.
Chadin, Andrey V.
Valikhov, Marat P.
Chekhonin, Vladimir P.
author_sort Sosnovtseva, Anastasiia O.
collection PubMed
description The regeneration of nerve tissue after spinal cord injury is a complex and poorly understood process. Medication and surgery are not very effective treatments for patients with spinal cord injuries. Gene therapy is a popular approach for the treatment of such patients. The delivery of therapeutic genes is carried out in a variety of ways, such as direct injection of therapeutic vectors at the site of injury, retrograde delivery of vectors, and ex vivo therapy using various cells. Recombinant adenoviruses are often used as vectors for gene transfer. This review discusses the advantages, limitations and prospects of adenovectors in spinal cord injury therapy.
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spelling pubmed-87845172022-01-25 Recombinant Adenoviruses for Delivery of Therapeutics Following Spinal Cord Injury Sosnovtseva, Anastasiia O. Stepanova, Olga V. Stepanenko, Aleksei A. Voronova, Anastasia D. Chadin, Andrey V. Valikhov, Marat P. Chekhonin, Vladimir P. Front Pharmacol Pharmacology The regeneration of nerve tissue after spinal cord injury is a complex and poorly understood process. Medication and surgery are not very effective treatments for patients with spinal cord injuries. Gene therapy is a popular approach for the treatment of such patients. The delivery of therapeutic genes is carried out in a variety of ways, such as direct injection of therapeutic vectors at the site of injury, retrograde delivery of vectors, and ex vivo therapy using various cells. Recombinant adenoviruses are often used as vectors for gene transfer. This review discusses the advantages, limitations and prospects of adenovectors in spinal cord injury therapy. Frontiers Media S.A. 2022-01-10 /pmc/articles/PMC8784517/ /pubmed/35082666 http://dx.doi.org/10.3389/fphar.2021.777628 Text en Copyright © 2022 Sosnovtseva, Stepanova, Stepanenko, Voronova, Chadin, Valikhov and Chekhonin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Sosnovtseva, Anastasiia O.
Stepanova, Olga V.
Stepanenko, Aleksei A.
Voronova, Anastasia D.
Chadin, Andrey V.
Valikhov, Marat P.
Chekhonin, Vladimir P.
Recombinant Adenoviruses for Delivery of Therapeutics Following Spinal Cord Injury
title Recombinant Adenoviruses for Delivery of Therapeutics Following Spinal Cord Injury
title_full Recombinant Adenoviruses for Delivery of Therapeutics Following Spinal Cord Injury
title_fullStr Recombinant Adenoviruses for Delivery of Therapeutics Following Spinal Cord Injury
title_full_unstemmed Recombinant Adenoviruses for Delivery of Therapeutics Following Spinal Cord Injury
title_short Recombinant Adenoviruses for Delivery of Therapeutics Following Spinal Cord Injury
title_sort recombinant adenoviruses for delivery of therapeutics following spinal cord injury
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784517/
https://www.ncbi.nlm.nih.gov/pubmed/35082666
http://dx.doi.org/10.3389/fphar.2021.777628
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