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Awareness and Use of Post-exposure Prophylaxis for HIV Prevention Among Men Who Have Sex With Men: A Systematic Review and Meta-Analysis

Background: The use of post-exposure prophylaxis (PEP) is effective in reducing HIV risk, but it is underused by men who have sex with men (MSM) due to certain psychological and sociostructural factors. This article assessed the awareness and use of PEP among MSM in an effort to increase the visibil...

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Autores principales: Jin, Junyan, Sun, Runsong, Mu, Tingting, Jiang, Taiyi, Dai, Lili, Lu, Hongyan, Ren, Xianlong, Chen, Jing, Ye, Jingrong, Sun, Lijun, Wu, Hao, Zhang, Tong, Zou, Huachun, Su, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784556/
https://www.ncbi.nlm.nih.gov/pubmed/35083243
http://dx.doi.org/10.3389/fmed.2021.783626
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author Jin, Junyan
Sun, Runsong
Mu, Tingting
Jiang, Taiyi
Dai, Lili
Lu, Hongyan
Ren, Xianlong
Chen, Jing
Ye, Jingrong
Sun, Lijun
Wu, Hao
Zhang, Tong
Zou, Huachun
Su, Bin
author_facet Jin, Junyan
Sun, Runsong
Mu, Tingting
Jiang, Taiyi
Dai, Lili
Lu, Hongyan
Ren, Xianlong
Chen, Jing
Ye, Jingrong
Sun, Lijun
Wu, Hao
Zhang, Tong
Zou, Huachun
Su, Bin
author_sort Jin, Junyan
collection PubMed
description Background: The use of post-exposure prophylaxis (PEP) is effective in reducing HIV risk, but it is underused by men who have sex with men (MSM) due to certain psychological and sociostructural factors. This article assessed the awareness and use of PEP among MSM in an effort to increase the visibility and uptake of PEP among at-risk populations. Methods: We conducted a systematic literature search of the PubMed, Web of Science, PsycINFO, and Google Scholar electronic databases. Studies were screened for inclusion, and relevant data were abstracted, assessed for bias, and synthesized. Pooled effect estimates were calculated using random effects meta-analysis, meta-regression and subgroup analysis, and a qualitative review and risk of bias assessment were performed (PROSPERO, CRD42019123815). Results: Twenty eligible studies involving 12,579 MSM were included in the meta-analysis. The pooled estimate of the proportions of MSM who were aware of PEP was modest at 59.9% (95% CI: 50.5~68.7) and that of MSM who previously used PEP was very low at 4.9% (95% CI: 2.4~9.8). PEP awareness showed no clear change over time, while PEP use significantly changed over time. Multiple factors affected awareness, including educational attainment, race/ethnicity, levels of HIV stigma, access to condoms, and so on. Many factors could potentially impede or facilitate the use of PEP, such as income, lack of PEP information, and partnership. Conclusion: We observed that PEP is an underused HIV prevention strategy among MSM and that once MSM become aware of PEP, the majority are willing to use it if they are supported appropriately in terms of a range of individual, social, and structural barriers. Systematic Review Registration: http://www.cdr.york.ac.uk/prospero, PROSPERO [CRD42019123815].
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spelling pubmed-87845562022-01-25 Awareness and Use of Post-exposure Prophylaxis for HIV Prevention Among Men Who Have Sex With Men: A Systematic Review and Meta-Analysis Jin, Junyan Sun, Runsong Mu, Tingting Jiang, Taiyi Dai, Lili Lu, Hongyan Ren, Xianlong Chen, Jing Ye, Jingrong Sun, Lijun Wu, Hao Zhang, Tong Zou, Huachun Su, Bin Front Med (Lausanne) Medicine Background: The use of post-exposure prophylaxis (PEP) is effective in reducing HIV risk, but it is underused by men who have sex with men (MSM) due to certain psychological and sociostructural factors. This article assessed the awareness and use of PEP among MSM in an effort to increase the visibility and uptake of PEP among at-risk populations. Methods: We conducted a systematic literature search of the PubMed, Web of Science, PsycINFO, and Google Scholar electronic databases. Studies were screened for inclusion, and relevant data were abstracted, assessed for bias, and synthesized. Pooled effect estimates were calculated using random effects meta-analysis, meta-regression and subgroup analysis, and a qualitative review and risk of bias assessment were performed (PROSPERO, CRD42019123815). Results: Twenty eligible studies involving 12,579 MSM were included in the meta-analysis. The pooled estimate of the proportions of MSM who were aware of PEP was modest at 59.9% (95% CI: 50.5~68.7) and that of MSM who previously used PEP was very low at 4.9% (95% CI: 2.4~9.8). PEP awareness showed no clear change over time, while PEP use significantly changed over time. Multiple factors affected awareness, including educational attainment, race/ethnicity, levels of HIV stigma, access to condoms, and so on. Many factors could potentially impede or facilitate the use of PEP, such as income, lack of PEP information, and partnership. Conclusion: We observed that PEP is an underused HIV prevention strategy among MSM and that once MSM become aware of PEP, the majority are willing to use it if they are supported appropriately in terms of a range of individual, social, and structural barriers. Systematic Review Registration: http://www.cdr.york.ac.uk/prospero, PROSPERO [CRD42019123815]. Frontiers Media S.A. 2022-01-10 /pmc/articles/PMC8784556/ /pubmed/35083243 http://dx.doi.org/10.3389/fmed.2021.783626 Text en Copyright © 2022 Jin, Sun, Mu, Jiang, Dai, Lu, Ren, Chen, Ye, Sun, Wu, Zhang, Zou and Su. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Jin, Junyan
Sun, Runsong
Mu, Tingting
Jiang, Taiyi
Dai, Lili
Lu, Hongyan
Ren, Xianlong
Chen, Jing
Ye, Jingrong
Sun, Lijun
Wu, Hao
Zhang, Tong
Zou, Huachun
Su, Bin
Awareness and Use of Post-exposure Prophylaxis for HIV Prevention Among Men Who Have Sex With Men: A Systematic Review and Meta-Analysis
title Awareness and Use of Post-exposure Prophylaxis for HIV Prevention Among Men Who Have Sex With Men: A Systematic Review and Meta-Analysis
title_full Awareness and Use of Post-exposure Prophylaxis for HIV Prevention Among Men Who Have Sex With Men: A Systematic Review and Meta-Analysis
title_fullStr Awareness and Use of Post-exposure Prophylaxis for HIV Prevention Among Men Who Have Sex With Men: A Systematic Review and Meta-Analysis
title_full_unstemmed Awareness and Use of Post-exposure Prophylaxis for HIV Prevention Among Men Who Have Sex With Men: A Systematic Review and Meta-Analysis
title_short Awareness and Use of Post-exposure Prophylaxis for HIV Prevention Among Men Who Have Sex With Men: A Systematic Review and Meta-Analysis
title_sort awareness and use of post-exposure prophylaxis for hiv prevention among men who have sex with men: a systematic review and meta-analysis
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784556/
https://www.ncbi.nlm.nih.gov/pubmed/35083243
http://dx.doi.org/10.3389/fmed.2021.783626
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