New insights into the molecular mechanisms of glutaminase C inhibitors in cancer cells using serial room temperature crystallography

Cancer cells frequently exhibit uncoupling of the glycolytic pathway from the TCA cycle (i.e., the “Warburg effect”) and as a result, often become dependent on their ability to increase glutamine catabolism. The mitochondrial enzyme Glutaminase C (GAC) helps to satisfy this ‘glutamine addiction’ of...

Descripción completa

Detalles Bibliográficos
Autores principales: Milano, Shawn K., Huang, Qingqiu, Nguyen, Thuy-Tien T., Ramachandran, Sekar, Finke, Aaron, Kriksunov, Irina, Schuller, David J., Szebenyi, D. Marian, Arenholz, Elke, McDermott, Lee A., Sukumar, N., Cerione, Richard A., Katt, William P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784640/
https://www.ncbi.nlm.nih.gov/pubmed/34954143
http://dx.doi.org/10.1016/j.jbc.2021.101535

Ejemplares similares

Ejemplares similares