SIDT1 plays a key role in type I IFN responses to nucleic acids in plasmacytoid dendritic cells and mediates the pathogenesis of an imiquimod-induced psoriasis model

BACKGROUND: Type I IFN (IFN-I) is a family of cytokines involved in the pathogenesis of autoimmune and autoinflammatory diseases such as psoriasis. SIDT1 is an ER-resident protein expressed in the lymphoid lineage, and involved in anti-viral IFN-I responses in vivo, through an unclear mechanism. Her...

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Detalles Bibliográficos
Autores principales: Morell, María, Varela, Nieves, Castillejo-López, Casimiro, Coppard, Céline, Luque, María José, Wu, Ying-Yu, Martín-Morales, Natividad, Pérez-Cózar, Francisco, Gómez-Hernández, Gonzalo, Kumar, Ramesh, O'Valle, Francisco, Alarcón-Riquelme, Marta E., Marañón, Concepción
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784643/
https://www.ncbi.nlm.nih.gov/pubmed/35065421
http://dx.doi.org/10.1016/j.ebiom.2021.103808

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