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The Development of Single-Cell Metabolism and Its Role in Studying Cancer Emergent Properties

Metabolic reprogramming is one of the hallmarks of malignant tumors, which provides energy and material basis for tumor rapid proliferation, immune escape, as well as extensive invasion and metastasis. Blocking the energy and material supply of tumor cells is one of the strategies to treat tumor, ho...

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Autores principales: Wei, Dingju, Xu, Meng, Wang, Zhihua, Tong, Jingjing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784738/
https://www.ncbi.nlm.nih.gov/pubmed/35083160
http://dx.doi.org/10.3389/fonc.2021.814085
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author Wei, Dingju
Xu, Meng
Wang, Zhihua
Tong, Jingjing
author_facet Wei, Dingju
Xu, Meng
Wang, Zhihua
Tong, Jingjing
author_sort Wei, Dingju
collection PubMed
description Metabolic reprogramming is one of the hallmarks of malignant tumors, which provides energy and material basis for tumor rapid proliferation, immune escape, as well as extensive invasion and metastasis. Blocking the energy and material supply of tumor cells is one of the strategies to treat tumor, however tumor cell metabolic heterogeneity prevents metabolic-based anti-cancer treatment. Therefore, searching for the key metabolic factors that regulate cell cancerous change and tumor recurrence has become a major challenge. Emerging technology––single-cell metabolomics is different from the traditional metabolomics that obtains average information of a group of cells. Single-cell metabolomics identifies the metabolites of single cells in different states by mass spectrometry, and captures the molecular biological information of the energy and substances synthesized in single cells, which provides more detailed information for tumor treatment metabolic target screening. This review will combine the current research status of tumor cell metabolism with the advantages of single-cell metabolomics technology, and explore the role of single-cell sequencing technology in searching key factors regulating tumor metabolism. The addition of single-cell technology will accelerate the development of metabolism-based anti-cancer strategies, which may greatly improve the prognostic survival rate of cancer patients.
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spelling pubmed-87847382022-01-25 The Development of Single-Cell Metabolism and Its Role in Studying Cancer Emergent Properties Wei, Dingju Xu, Meng Wang, Zhihua Tong, Jingjing Front Oncol Oncology Metabolic reprogramming is one of the hallmarks of malignant tumors, which provides energy and material basis for tumor rapid proliferation, immune escape, as well as extensive invasion and metastasis. Blocking the energy and material supply of tumor cells is one of the strategies to treat tumor, however tumor cell metabolic heterogeneity prevents metabolic-based anti-cancer treatment. Therefore, searching for the key metabolic factors that regulate cell cancerous change and tumor recurrence has become a major challenge. Emerging technology––single-cell metabolomics is different from the traditional metabolomics that obtains average information of a group of cells. Single-cell metabolomics identifies the metabolites of single cells in different states by mass spectrometry, and captures the molecular biological information of the energy and substances synthesized in single cells, which provides more detailed information for tumor treatment metabolic target screening. This review will combine the current research status of tumor cell metabolism with the advantages of single-cell metabolomics technology, and explore the role of single-cell sequencing technology in searching key factors regulating tumor metabolism. The addition of single-cell technology will accelerate the development of metabolism-based anti-cancer strategies, which may greatly improve the prognostic survival rate of cancer patients. Frontiers Media S.A. 2022-01-10 /pmc/articles/PMC8784738/ /pubmed/35083160 http://dx.doi.org/10.3389/fonc.2021.814085 Text en Copyright © 2022 Wei, Xu, Wang and Tong https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Wei, Dingju
Xu, Meng
Wang, Zhihua
Tong, Jingjing
The Development of Single-Cell Metabolism and Its Role in Studying Cancer Emergent Properties
title The Development of Single-Cell Metabolism and Its Role in Studying Cancer Emergent Properties
title_full The Development of Single-Cell Metabolism and Its Role in Studying Cancer Emergent Properties
title_fullStr The Development of Single-Cell Metabolism and Its Role in Studying Cancer Emergent Properties
title_full_unstemmed The Development of Single-Cell Metabolism and Its Role in Studying Cancer Emergent Properties
title_short The Development of Single-Cell Metabolism and Its Role in Studying Cancer Emergent Properties
title_sort development of single-cell metabolism and its role in studying cancer emergent properties
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784738/
https://www.ncbi.nlm.nih.gov/pubmed/35083160
http://dx.doi.org/10.3389/fonc.2021.814085
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