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The Potential Mechanism of Cancer Patients Appearing More Vulnerable to SARS-CoV-2 and Poor Outcomes: A Pan-Cancer Bioinformatics Analysis
To explore the potential mechanism of cancer patients appearing more vulnerable to SARS-CoV-2 infection and poor COVID-19 outcomes, we conducted an integrative bioinformatics analysis for SARS-CoV-2-required genes and host genes and variants related to SARS-CoV-2 susceptibility and COVID-19 severity...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784815/ https://www.ncbi.nlm.nih.gov/pubmed/35082790 http://dx.doi.org/10.3389/fimmu.2021.804387 |
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author | Huang, Xinwei Liang, Huazheng Zhang, Hong Tian, Li Cong, Peilin Wu, Tingmei Zhang, Qian Gao, Xiaofei Li, Wanrong Chen, Aiwen Zhang, Yuxin Dong, Qianyu Wan, Hanxi He, Mengfan Dai, Danqing Li, Zhen Xiong, Lize |
author_facet | Huang, Xinwei Liang, Huazheng Zhang, Hong Tian, Li Cong, Peilin Wu, Tingmei Zhang, Qian Gao, Xiaofei Li, Wanrong Chen, Aiwen Zhang, Yuxin Dong, Qianyu Wan, Hanxi He, Mengfan Dai, Danqing Li, Zhen Xiong, Lize |
author_sort | Huang, Xinwei |
collection | PubMed |
description | To explore the potential mechanism of cancer patients appearing more vulnerable to SARS-CoV-2 infection and poor COVID-19 outcomes, we conducted an integrative bioinformatics analysis for SARS-CoV-2-required genes and host genes and variants related to SARS-CoV-2 susceptibility and COVID-19 severity. BLCA, HNSC, KIRC, KIRP, LGG, PCPG, PRAD, TGCT, and THCA patients carrying rs10774671-A (OAS1) genotype may be more likely to have poor COVID-19 outcomes relative to those who carry rs10774671-G, because individuals carrying rs10774671-A will have lower expression of OAS1, which serves as a protective factor against SARS-CoV-2 processes and poor COVID-19 outcomes. SARS-CoV-2-required genes were correlated with TME, immune infiltration, overall survival, and anti-cancer drug sensitivity. CHOL patients may have a higher risk of SARS-CoV-2 infection than healthy subjects. SARS-CoV-2-induced ACE2 and NPC1 elevation may have a negative influence on the immune responses of LUSC and CD8+T infiltration of LUAD, and negatively affect the sensitivity of anti-lung cancer drugs. LUSC and LUAD patients may have a varying degree of adverse outcomes if they are infected with SARS-CoV-2. miR-760 may target and inhibit ACE2 expression. Cancer patients appearing vulnerable to SARS-CoV-2 infection and having poor COVID-19 outcomes may be partly due to host genetic factors and dysregulation of SARS-CoV-2-required genes. OAS1, ACE2, and miR-760 could serve as the treatment and intervention targets for SARS-CoV-2. |
format | Online Article Text |
id | pubmed-8784815 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87848152022-01-25 The Potential Mechanism of Cancer Patients Appearing More Vulnerable to SARS-CoV-2 and Poor Outcomes: A Pan-Cancer Bioinformatics Analysis Huang, Xinwei Liang, Huazheng Zhang, Hong Tian, Li Cong, Peilin Wu, Tingmei Zhang, Qian Gao, Xiaofei Li, Wanrong Chen, Aiwen Zhang, Yuxin Dong, Qianyu Wan, Hanxi He, Mengfan Dai, Danqing Li, Zhen Xiong, Lize Front Immunol Immunology To explore the potential mechanism of cancer patients appearing more vulnerable to SARS-CoV-2 infection and poor COVID-19 outcomes, we conducted an integrative bioinformatics analysis for SARS-CoV-2-required genes and host genes and variants related to SARS-CoV-2 susceptibility and COVID-19 severity. BLCA, HNSC, KIRC, KIRP, LGG, PCPG, PRAD, TGCT, and THCA patients carrying rs10774671-A (OAS1) genotype may be more likely to have poor COVID-19 outcomes relative to those who carry rs10774671-G, because individuals carrying rs10774671-A will have lower expression of OAS1, which serves as a protective factor against SARS-CoV-2 processes and poor COVID-19 outcomes. SARS-CoV-2-required genes were correlated with TME, immune infiltration, overall survival, and anti-cancer drug sensitivity. CHOL patients may have a higher risk of SARS-CoV-2 infection than healthy subjects. SARS-CoV-2-induced ACE2 and NPC1 elevation may have a negative influence on the immune responses of LUSC and CD8+T infiltration of LUAD, and negatively affect the sensitivity of anti-lung cancer drugs. LUSC and LUAD patients may have a varying degree of adverse outcomes if they are infected with SARS-CoV-2. miR-760 may target and inhibit ACE2 expression. Cancer patients appearing vulnerable to SARS-CoV-2 infection and having poor COVID-19 outcomes may be partly due to host genetic factors and dysregulation of SARS-CoV-2-required genes. OAS1, ACE2, and miR-760 could serve as the treatment and intervention targets for SARS-CoV-2. Frontiers Media S.A. 2022-01-10 /pmc/articles/PMC8784815/ /pubmed/35082790 http://dx.doi.org/10.3389/fimmu.2021.804387 Text en Copyright © 2022 Huang, Liang, Zhang, Tian, Cong, Wu, Zhang, Gao, Li, Chen, Zhang, Dong, Wan, He, Dai, Li and Xiong https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Huang, Xinwei Liang, Huazheng Zhang, Hong Tian, Li Cong, Peilin Wu, Tingmei Zhang, Qian Gao, Xiaofei Li, Wanrong Chen, Aiwen Zhang, Yuxin Dong, Qianyu Wan, Hanxi He, Mengfan Dai, Danqing Li, Zhen Xiong, Lize The Potential Mechanism of Cancer Patients Appearing More Vulnerable to SARS-CoV-2 and Poor Outcomes: A Pan-Cancer Bioinformatics Analysis |
title | The Potential Mechanism of Cancer Patients Appearing More Vulnerable to SARS-CoV-2 and Poor Outcomes: A Pan-Cancer Bioinformatics Analysis |
title_full | The Potential Mechanism of Cancer Patients Appearing More Vulnerable to SARS-CoV-2 and Poor Outcomes: A Pan-Cancer Bioinformatics Analysis |
title_fullStr | The Potential Mechanism of Cancer Patients Appearing More Vulnerable to SARS-CoV-2 and Poor Outcomes: A Pan-Cancer Bioinformatics Analysis |
title_full_unstemmed | The Potential Mechanism of Cancer Patients Appearing More Vulnerable to SARS-CoV-2 and Poor Outcomes: A Pan-Cancer Bioinformatics Analysis |
title_short | The Potential Mechanism of Cancer Patients Appearing More Vulnerable to SARS-CoV-2 and Poor Outcomes: A Pan-Cancer Bioinformatics Analysis |
title_sort | potential mechanism of cancer patients appearing more vulnerable to sars-cov-2 and poor outcomes: a pan-cancer bioinformatics analysis |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784815/ https://www.ncbi.nlm.nih.gov/pubmed/35082790 http://dx.doi.org/10.3389/fimmu.2021.804387 |
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