Cargando…
Mendelian randomization analysis of the causal impact of body mass index and waist-hip ratio on rates of hospital admission
We analyze how measures of adiposity – body mass index (BMI) and waist hip ratio (WHR) – causally influence rates of hospital admission. Conventional analyses of this relationship are susceptible to omitted variable bias from variables that jointly influence both hospital admission and adipose statu...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Science
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784824/ https://www.ncbi.nlm.nih.gov/pubmed/34894623 http://dx.doi.org/10.1016/j.ehb.2021.101088 |
_version_ | 1784638824786165760 |
---|---|
author | Hazewinkel, Audinga-Dea Richmond, Rebecca C. Wade, Kaitlin H. Dixon, Padraig |
author_facet | Hazewinkel, Audinga-Dea Richmond, Rebecca C. Wade, Kaitlin H. Dixon, Padraig |
author_sort | Hazewinkel, Audinga-Dea |
collection | PubMed |
description | We analyze how measures of adiposity – body mass index (BMI) and waist hip ratio (WHR) – causally influence rates of hospital admission. Conventional analyses of this relationship are susceptible to omitted variable bias from variables that jointly influence both hospital admission and adipose status. We implement a novel quasi-Poisson instrumental variable model in a Mendelian randomization framework, identifying causal effects from random perturbations to germline genetic variation. We estimate the individual and joint effects of BMI, WHR, and WHR adjusted for BMI. We also implement multivariable instrumental variable methods in which the causal effect of one exposure is estimated conditionally on the causal effect of another exposure. Data on 310,471 participants and over 550,000 inpatient admissions in the UK Biobank were used to perform one-sample and two-sample Mendelian randomization analyses. The results supported a causal role of adiposity on hospital admissions, with consistency across all estimates and sensitivity analyses. Point estimates were generally larger than estimates from comparable observational specifications. We observed an attenuation of the BMI effect when adjusting for WHR in the multivariable Mendelian randomization analyses, suggesting that an adverse fat distribution, rather than a higher BMI itself, may drive the relationship between adiposity and risk of hospital admission. |
format | Online Article Text |
id | pubmed-8784824 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-87848242022-01-31 Mendelian randomization analysis of the causal impact of body mass index and waist-hip ratio on rates of hospital admission Hazewinkel, Audinga-Dea Richmond, Rebecca C. Wade, Kaitlin H. Dixon, Padraig Econ Hum Biol Article We analyze how measures of adiposity – body mass index (BMI) and waist hip ratio (WHR) – causally influence rates of hospital admission. Conventional analyses of this relationship are susceptible to omitted variable bias from variables that jointly influence both hospital admission and adipose status. We implement a novel quasi-Poisson instrumental variable model in a Mendelian randomization framework, identifying causal effects from random perturbations to germline genetic variation. We estimate the individual and joint effects of BMI, WHR, and WHR adjusted for BMI. We also implement multivariable instrumental variable methods in which the causal effect of one exposure is estimated conditionally on the causal effect of another exposure. Data on 310,471 participants and over 550,000 inpatient admissions in the UK Biobank were used to perform one-sample and two-sample Mendelian randomization analyses. The results supported a causal role of adiposity on hospital admissions, with consistency across all estimates and sensitivity analyses. Point estimates were generally larger than estimates from comparable observational specifications. We observed an attenuation of the BMI effect when adjusting for WHR in the multivariable Mendelian randomization analyses, suggesting that an adverse fat distribution, rather than a higher BMI itself, may drive the relationship between adiposity and risk of hospital admission. Elsevier Science 2022-01 /pmc/articles/PMC8784824/ /pubmed/34894623 http://dx.doi.org/10.1016/j.ehb.2021.101088 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hazewinkel, Audinga-Dea Richmond, Rebecca C. Wade, Kaitlin H. Dixon, Padraig Mendelian randomization analysis of the causal impact of body mass index and waist-hip ratio on rates of hospital admission |
title | Mendelian randomization analysis of the causal impact of body mass index and waist-hip ratio on rates of hospital admission |
title_full | Mendelian randomization analysis of the causal impact of body mass index and waist-hip ratio on rates of hospital admission |
title_fullStr | Mendelian randomization analysis of the causal impact of body mass index and waist-hip ratio on rates of hospital admission |
title_full_unstemmed | Mendelian randomization analysis of the causal impact of body mass index and waist-hip ratio on rates of hospital admission |
title_short | Mendelian randomization analysis of the causal impact of body mass index and waist-hip ratio on rates of hospital admission |
title_sort | mendelian randomization analysis of the causal impact of body mass index and waist-hip ratio on rates of hospital admission |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784824/ https://www.ncbi.nlm.nih.gov/pubmed/34894623 http://dx.doi.org/10.1016/j.ehb.2021.101088 |
work_keys_str_mv | AT hazewinkelaudingadea mendelianrandomizationanalysisofthecausalimpactofbodymassindexandwaisthipratioonratesofhospitaladmission AT richmondrebeccac mendelianrandomizationanalysisofthecausalimpactofbodymassindexandwaisthipratioonratesofhospitaladmission AT wadekaitlinh mendelianrandomizationanalysisofthecausalimpactofbodymassindexandwaisthipratioonratesofhospitaladmission AT dixonpadraig mendelianrandomizationanalysisofthecausalimpactofbodymassindexandwaisthipratioonratesofhospitaladmission |