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Tannins in the Treatment of Diabetic Neuropathic Pain: Research Progress and Future Challenges

Diabetes mellitus and its consequences continue to put a significant demand on medical resources across the world. Diabetic neuropathic pain (DNP) is a frequent diabetes mellitus chronic microvascular outcome. Allodynia, hyperalgesia, and aberrant or lack of nerve fibre sensation are all symptoms of...

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Autores principales: Omar, Norsuhana, Ismail, Che Aishah Nazariah, Long, Idris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784866/
https://www.ncbi.nlm.nih.gov/pubmed/35082680
http://dx.doi.org/10.3389/fphar.2021.805854
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author Omar, Norsuhana
Ismail, Che Aishah Nazariah
Long, Idris
author_facet Omar, Norsuhana
Ismail, Che Aishah Nazariah
Long, Idris
author_sort Omar, Norsuhana
collection PubMed
description Diabetes mellitus and its consequences continue to put a significant demand on medical resources across the world. Diabetic neuropathic pain (DNP) is a frequent diabetes mellitus chronic microvascular outcome. Allodynia, hyperalgesia, and aberrant or lack of nerve fibre sensation are all symptoms of DNP. These clinical characteristics will lead to worse quality of life, sleep disruption, depression, and increased mortality. Although the availability of numerous medications that alleviate the symptoms of DNP, the lack of long-term efficacy and unfavourable side effects highlight the urgent need for novel treatment strategies. This review paper systematically analysed the preclinical research on the treatment of DNP using plant phytochemicals that contain only tannins. A total of 10 original articles involved in in-vivo and in-vitro experiments addressing the promising benefits of phytochemical tannins on DNP were examined between 2008 and 2021. The information given implies that these phytochemicals may have relevant pharmacological effects on DNP symptoms through their antihyperalgesic, anti-inflammatory, and antioxidant properties; however, because of the limited sample size and limitations of the studies conducted so far, we were unable to make definitive conclusions. Before tannins may be employed as therapeutic agents for DNP, more study is needed to establish the specific molecular mechanism for all of these activities along the pain pathway and examine the side effects of tannins in the treatment of DNP.
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spelling pubmed-87848662022-01-25 Tannins in the Treatment of Diabetic Neuropathic Pain: Research Progress and Future Challenges Omar, Norsuhana Ismail, Che Aishah Nazariah Long, Idris Front Pharmacol Pharmacology Diabetes mellitus and its consequences continue to put a significant demand on medical resources across the world. Diabetic neuropathic pain (DNP) is a frequent diabetes mellitus chronic microvascular outcome. Allodynia, hyperalgesia, and aberrant or lack of nerve fibre sensation are all symptoms of DNP. These clinical characteristics will lead to worse quality of life, sleep disruption, depression, and increased mortality. Although the availability of numerous medications that alleviate the symptoms of DNP, the lack of long-term efficacy and unfavourable side effects highlight the urgent need for novel treatment strategies. This review paper systematically analysed the preclinical research on the treatment of DNP using plant phytochemicals that contain only tannins. A total of 10 original articles involved in in-vivo and in-vitro experiments addressing the promising benefits of phytochemical tannins on DNP were examined between 2008 and 2021. The information given implies that these phytochemicals may have relevant pharmacological effects on DNP symptoms through their antihyperalgesic, anti-inflammatory, and antioxidant properties; however, because of the limited sample size and limitations of the studies conducted so far, we were unable to make definitive conclusions. Before tannins may be employed as therapeutic agents for DNP, more study is needed to establish the specific molecular mechanism for all of these activities along the pain pathway and examine the side effects of tannins in the treatment of DNP. Frontiers Media S.A. 2022-01-10 /pmc/articles/PMC8784866/ /pubmed/35082680 http://dx.doi.org/10.3389/fphar.2021.805854 Text en Copyright © 2022 Omar, Ismail and Long. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Omar, Norsuhana
Ismail, Che Aishah Nazariah
Long, Idris
Tannins in the Treatment of Diabetic Neuropathic Pain: Research Progress and Future Challenges
title Tannins in the Treatment of Diabetic Neuropathic Pain: Research Progress and Future Challenges
title_full Tannins in the Treatment of Diabetic Neuropathic Pain: Research Progress and Future Challenges
title_fullStr Tannins in the Treatment of Diabetic Neuropathic Pain: Research Progress and Future Challenges
title_full_unstemmed Tannins in the Treatment of Diabetic Neuropathic Pain: Research Progress and Future Challenges
title_short Tannins in the Treatment of Diabetic Neuropathic Pain: Research Progress and Future Challenges
title_sort tannins in the treatment of diabetic neuropathic pain: research progress and future challenges
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784866/
https://www.ncbi.nlm.nih.gov/pubmed/35082680
http://dx.doi.org/10.3389/fphar.2021.805854
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