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FAIM-L - SIVA-1: Two Modulators of XIAP in Non-Apoptotic Caspase Function

Apoptosis is crucial for the correct development of the nervous system. In adulthood, the same protein machinery involved in programmed cell death can control neuronal adaptiveness through modulation of synaptic pruning and synaptic plasticity processes. Caspases are the main executioners in these m...

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Detalles Bibliográficos
Autores principales: Coccia, Elena, Solé, Montse, Comella, Joan X
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784879/
https://www.ncbi.nlm.nih.gov/pubmed/35083225
http://dx.doi.org/10.3389/fcell.2021.826037
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author Coccia, Elena
Solé, Montse
Comella, Joan X
author_facet Coccia, Elena
Solé, Montse
Comella, Joan X
author_sort Coccia, Elena
collection PubMed
description Apoptosis is crucial for the correct development of the nervous system. In adulthood, the same protein machinery involved in programmed cell death can control neuronal adaptiveness through modulation of synaptic pruning and synaptic plasticity processes. Caspases are the main executioners in these molecular pathways, and their strict regulation is essential to perform neuronal remodeling preserving cell survival. FAIM-L and SIVA-1 are regulators of caspase activation. In this review we will focus on FAIM-L and SIVA-1 as two functional antagonists that modulate non-apoptotic caspase activity in neurons. Their participation in long-term depression and neurite pruning will be described in base of the latest studies performed. In addition, the association of FAIM-L non-apoptotic functions with the neurodegeneration process will be reviewed.
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spelling pubmed-87848792022-01-25 FAIM-L - SIVA-1: Two Modulators of XIAP in Non-Apoptotic Caspase Function Coccia, Elena Solé, Montse Comella, Joan X Front Cell Dev Biol Cell and Developmental Biology Apoptosis is crucial for the correct development of the nervous system. In adulthood, the same protein machinery involved in programmed cell death can control neuronal adaptiveness through modulation of synaptic pruning and synaptic plasticity processes. Caspases are the main executioners in these molecular pathways, and their strict regulation is essential to perform neuronal remodeling preserving cell survival. FAIM-L and SIVA-1 are regulators of caspase activation. In this review we will focus on FAIM-L and SIVA-1 as two functional antagonists that modulate non-apoptotic caspase activity in neurons. Their participation in long-term depression and neurite pruning will be described in base of the latest studies performed. In addition, the association of FAIM-L non-apoptotic functions with the neurodegeneration process will be reviewed. Frontiers Media S.A. 2022-01-10 /pmc/articles/PMC8784879/ /pubmed/35083225 http://dx.doi.org/10.3389/fcell.2021.826037 Text en Copyright © 2022 Coccia, Solé and Comella. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Coccia, Elena
Solé, Montse
Comella, Joan X
FAIM-L - SIVA-1: Two Modulators of XIAP in Non-Apoptotic Caspase Function
title FAIM-L - SIVA-1: Two Modulators of XIAP in Non-Apoptotic Caspase Function
title_full FAIM-L - SIVA-1: Two Modulators of XIAP in Non-Apoptotic Caspase Function
title_fullStr FAIM-L - SIVA-1: Two Modulators of XIAP in Non-Apoptotic Caspase Function
title_full_unstemmed FAIM-L - SIVA-1: Two Modulators of XIAP in Non-Apoptotic Caspase Function
title_short FAIM-L - SIVA-1: Two Modulators of XIAP in Non-Apoptotic Caspase Function
title_sort faim-l - siva-1: two modulators of xiap in non-apoptotic caspase function
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784879/
https://www.ncbi.nlm.nih.gov/pubmed/35083225
http://dx.doi.org/10.3389/fcell.2021.826037
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