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Vaccination in Leishmaniasis: A Review Article
Leishmaniasis is caused by protozoan Leishmania parasites that are transmitted through female sandfly bites. The disease is predominantly endemic to the tropics and semi-tropics and has been reported in more than 98 countries. Due to the side effects of anti-Leishmania drugs and the emergence of dru...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Pasteur Institute of Iran
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784899/ https://www.ncbi.nlm.nih.gov/pubmed/34952558 http://dx.doi.org/10.52547/ibj.26.1.35 |
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author | Abdellahi, Latifeh Iraji, Fariba Mahmoudabadi, Anahita Hejazi, Seyed Hossein |
author_facet | Abdellahi, Latifeh Iraji, Fariba Mahmoudabadi, Anahita Hejazi, Seyed Hossein |
author_sort | Abdellahi, Latifeh |
collection | PubMed |
description | Leishmaniasis is caused by protozoan Leishmania parasites that are transmitted through female sandfly bites. The disease is predominantly endemic to the tropics and semi-tropics and has been reported in more than 98 countries. Due to the side effects of anti-Leishmania drugs and the emergence of drug-resistant isolates, there is currently no encouraging prospect of introducing an effective therapy for the disease. Hence, it seems that the key to disease control management is the introduction of an effective vaccine, particularly against its cutaneous form. Advances in understanding underlying immune mechanisms are feasibale using a variety of candidate antigens, including attenuated live parasites, crude antigens, pure or recombinant Leishmania proteins, Leishmania genes encoding protective proteins, as well as immune system activators from the saliva of parasite vectors. However, there is still no vaccine against different types of human leishmaniasis. In this study, we review the works conducted or being performed in this field. |
format | Online Article Text |
id | pubmed-8784899 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Pasteur Institute of Iran |
record_format | MEDLINE/PubMed |
spelling | pubmed-87848992022-02-07 Vaccination in Leishmaniasis: A Review Article Abdellahi, Latifeh Iraji, Fariba Mahmoudabadi, Anahita Hejazi, Seyed Hossein Iran Biomed J Review Article Leishmaniasis is caused by protozoan Leishmania parasites that are transmitted through female sandfly bites. The disease is predominantly endemic to the tropics and semi-tropics and has been reported in more than 98 countries. Due to the side effects of anti-Leishmania drugs and the emergence of drug-resistant isolates, there is currently no encouraging prospect of introducing an effective therapy for the disease. Hence, it seems that the key to disease control management is the introduction of an effective vaccine, particularly against its cutaneous form. Advances in understanding underlying immune mechanisms are feasibale using a variety of candidate antigens, including attenuated live parasites, crude antigens, pure or recombinant Leishmania proteins, Leishmania genes encoding protective proteins, as well as immune system activators from the saliva of parasite vectors. However, there is still no vaccine against different types of human leishmaniasis. In this study, we review the works conducted or being performed in this field. Pasteur Institute of Iran 2022-01 2021-12-20 /pmc/articles/PMC8784899/ /pubmed/34952558 http://dx.doi.org/10.52547/ibj.26.1.35 Text en https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Abdellahi, Latifeh Iraji, Fariba Mahmoudabadi, Anahita Hejazi, Seyed Hossein Vaccination in Leishmaniasis: A Review Article |
title | Vaccination in Leishmaniasis: A Review Article |
title_full | Vaccination in Leishmaniasis: A Review Article |
title_fullStr | Vaccination in Leishmaniasis: A Review Article |
title_full_unstemmed | Vaccination in Leishmaniasis: A Review Article |
title_short | Vaccination in Leishmaniasis: A Review Article |
title_sort | vaccination in leishmaniasis: a review article |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784899/ https://www.ncbi.nlm.nih.gov/pubmed/34952558 http://dx.doi.org/10.52547/ibj.26.1.35 |
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