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Vaccination in Leishmaniasis: A Review Article

Leishmaniasis is caused by protozoan Leishmania parasites that are transmitted through female sandfly bites. The disease is predominantly endemic to the tropics and semi-tropics and has been reported in more than 98 countries. Due to the side effects of anti-Leishmania drugs and the emergence of dru...

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Autores principales: Abdellahi, Latifeh, Iraji, Fariba, Mahmoudabadi, Anahita, Hejazi, Seyed Hossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pasteur Institute of Iran 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784899/
https://www.ncbi.nlm.nih.gov/pubmed/34952558
http://dx.doi.org/10.52547/ibj.26.1.35
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author Abdellahi, Latifeh
Iraji, Fariba
Mahmoudabadi, Anahita
Hejazi, Seyed Hossein
author_facet Abdellahi, Latifeh
Iraji, Fariba
Mahmoudabadi, Anahita
Hejazi, Seyed Hossein
author_sort Abdellahi, Latifeh
collection PubMed
description Leishmaniasis is caused by protozoan Leishmania parasites that are transmitted through female sandfly bites. The disease is predominantly endemic to the tropics and semi-tropics and has been reported in more than 98 countries. Due to the side effects of anti-Leishmania drugs and the emergence of drug-resistant isolates, there is currently no encouraging prospect of introducing an effective therapy for the disease. Hence, it seems that the key to disease control management is the introduction of an effective vaccine, particularly against its cutaneous form. Advances in understanding underlying immune mechanisms are feasibale using a variety of candidate antigens, including attenuated live parasites, crude antigens, pure or recombinant Leishmania proteins, Leishmania genes encoding protective proteins, as well as immune system activators from the saliva of parasite vectors. However, there is still no vaccine against different types of human leishmaniasis. In this study, we review the works conducted or being performed in this field.
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spelling pubmed-87848992022-02-07 Vaccination in Leishmaniasis: A Review Article Abdellahi, Latifeh Iraji, Fariba Mahmoudabadi, Anahita Hejazi, Seyed Hossein Iran Biomed J Review Article Leishmaniasis is caused by protozoan Leishmania parasites that are transmitted through female sandfly bites. The disease is predominantly endemic to the tropics and semi-tropics and has been reported in more than 98 countries. Due to the side effects of anti-Leishmania drugs and the emergence of drug-resistant isolates, there is currently no encouraging prospect of introducing an effective therapy for the disease. Hence, it seems that the key to disease control management is the introduction of an effective vaccine, particularly against its cutaneous form. Advances in understanding underlying immune mechanisms are feasibale using a variety of candidate antigens, including attenuated live parasites, crude antigens, pure or recombinant Leishmania proteins, Leishmania genes encoding protective proteins, as well as immune system activators from the saliva of parasite vectors. However, there is still no vaccine against different types of human leishmaniasis. In this study, we review the works conducted or being performed in this field. Pasteur Institute of Iran 2022-01 2021-12-20 /pmc/articles/PMC8784899/ /pubmed/34952558 http://dx.doi.org/10.52547/ibj.26.1.35 Text en https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Abdellahi, Latifeh
Iraji, Fariba
Mahmoudabadi, Anahita
Hejazi, Seyed Hossein
Vaccination in Leishmaniasis: A Review Article
title Vaccination in Leishmaniasis: A Review Article
title_full Vaccination in Leishmaniasis: A Review Article
title_fullStr Vaccination in Leishmaniasis: A Review Article
title_full_unstemmed Vaccination in Leishmaniasis: A Review Article
title_short Vaccination in Leishmaniasis: A Review Article
title_sort vaccination in leishmaniasis: a review article
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784899/
https://www.ncbi.nlm.nih.gov/pubmed/34952558
http://dx.doi.org/10.52547/ibj.26.1.35
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