Therapeutic potential of silymarin as a natural iron‐chelating agent in β‐thalassemia intermedia

Abnormal iron accumulation in vital organs is one of the major complications of β‐thalassemia intermedia (β‐TI). Silymarin, a flavonolignan isolated from Silybum marianum, significantly decreases the serum ferritin levels of β‐TI patients. This finding suggests silymarin as a safe and effective natu...

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Autores principales: Reisi, Nahid, Esmaeil, Nafiseh, Gharagozloo, Marjan, Moayedi, Behjat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784915/
https://www.ncbi.nlm.nih.gov/pubmed/35106163
http://dx.doi.org/10.1002/ccr3.5293
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author Reisi, Nahid
Esmaeil, Nafiseh
Gharagozloo, Marjan
Moayedi, Behjat
author_facet Reisi, Nahid
Esmaeil, Nafiseh
Gharagozloo, Marjan
Moayedi, Behjat
author_sort Reisi, Nahid
collection PubMed
description Abnormal iron accumulation in vital organs is one of the major complications of β‐thalassemia intermedia (β‐TI). Silymarin, a flavonolignan isolated from Silybum marianum, significantly decreases the serum ferritin levels of β‐TI patients. This finding suggests silymarin as a safe and effective natural iron‐chelating agent for the treatment of iron‐overloaded conditions.
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spelling pubmed-87849152022-01-31 Therapeutic potential of silymarin as a natural iron‐chelating agent in β‐thalassemia intermedia Reisi, Nahid Esmaeil, Nafiseh Gharagozloo, Marjan Moayedi, Behjat Clin Case Rep Case Report Abnormal iron accumulation in vital organs is one of the major complications of β‐thalassemia intermedia (β‐TI). Silymarin, a flavonolignan isolated from Silybum marianum, significantly decreases the serum ferritin levels of β‐TI patients. This finding suggests silymarin as a safe and effective natural iron‐chelating agent for the treatment of iron‐overloaded conditions. John Wiley and Sons Inc. 2022-01-24 /pmc/articles/PMC8784915/ /pubmed/35106163 http://dx.doi.org/10.1002/ccr3.5293 Text en © 2022 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Reisi, Nahid
Esmaeil, Nafiseh
Gharagozloo, Marjan
Moayedi, Behjat
Therapeutic potential of silymarin as a natural iron‐chelating agent in β‐thalassemia intermedia
title Therapeutic potential of silymarin as a natural iron‐chelating agent in β‐thalassemia intermedia
title_full Therapeutic potential of silymarin as a natural iron‐chelating agent in β‐thalassemia intermedia
title_fullStr Therapeutic potential of silymarin as a natural iron‐chelating agent in β‐thalassemia intermedia
title_full_unstemmed Therapeutic potential of silymarin as a natural iron‐chelating agent in β‐thalassemia intermedia
title_short Therapeutic potential of silymarin as a natural iron‐chelating agent in β‐thalassemia intermedia
title_sort therapeutic potential of silymarin as a natural iron‐chelating agent in β‐thalassemia intermedia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784915/
https://www.ncbi.nlm.nih.gov/pubmed/35106163
http://dx.doi.org/10.1002/ccr3.5293
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