COVID-19 in children with haematological malignancies

BACKGROUND: Children with cancer are not at increased risk of severe SARS-CoV-2 infection; however, adults with haematological malignancies have increased risk of severe infections compared with non-haematological malignancies. METHODS: We compared patients with haematological and non-haematological...

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Autores principales: Millen, Gerard Cathal, Arnold, Roland, Cazier, Jean-Baptiste, Curley, Helen, Feltbower, Richard, Gamble, Ashley, Glaser, Adam, Grundy, Richard G, Kirton, Laura, Lee, Lennard Y W, McCabe, Martin G, Palles, Claire, Phillips, Bob, Stiller, Charles A, Varnai, Csilla, Kearns, Pamela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8785070/
https://www.ncbi.nlm.nih.gov/pubmed/34301621
http://dx.doi.org/10.1136/archdischild-2021-322062
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author Millen, Gerard Cathal
Arnold, Roland
Cazier, Jean-Baptiste
Curley, Helen
Feltbower, Richard
Gamble, Ashley
Glaser, Adam
Grundy, Richard G
Kirton, Laura
Lee, Lennard Y W
McCabe, Martin G
Palles, Claire
Phillips, Bob
Stiller, Charles A
Varnai, Csilla
Kearns, Pamela
author_facet Millen, Gerard Cathal
Arnold, Roland
Cazier, Jean-Baptiste
Curley, Helen
Feltbower, Richard
Gamble, Ashley
Glaser, Adam
Grundy, Richard G
Kirton, Laura
Lee, Lennard Y W
McCabe, Martin G
Palles, Claire
Phillips, Bob
Stiller, Charles A
Varnai, Csilla
Kearns, Pamela
author_sort Millen, Gerard Cathal
collection PubMed
description BACKGROUND: Children with cancer are not at increased risk of severe SARS-CoV-2 infection; however, adults with haematological malignancies have increased risk of severe infections compared with non-haematological malignancies. METHODS: We compared patients with haematological and non-haematological malignancies enrolled in the UK Paediatric Coronavirus Cancer Monitoring Project between 12 March 2020 and 16 February 2021. Children who received stem cell transplantation were excluded. RESULTS: Only 2/62 patients with haematological malignancy had severe/critical infections, with an OR of 0.5 for patients with haematological compared with non-haematological malignancies. INTERPRETATION: Children with haematological malignancies are at no greater risk of severe SARS-CoV-2 infection than those with non-haematological malignancies.
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spelling pubmed-87850702022-02-04 COVID-19 in children with haematological malignancies Millen, Gerard Cathal Arnold, Roland Cazier, Jean-Baptiste Curley, Helen Feltbower, Richard Gamble, Ashley Glaser, Adam Grundy, Richard G Kirton, Laura Lee, Lennard Y W McCabe, Martin G Palles, Claire Phillips, Bob Stiller, Charles A Varnai, Csilla Kearns, Pamela Arch Dis Child Short Report BACKGROUND: Children with cancer are not at increased risk of severe SARS-CoV-2 infection; however, adults with haematological malignancies have increased risk of severe infections compared with non-haematological malignancies. METHODS: We compared patients with haematological and non-haematological malignancies enrolled in the UK Paediatric Coronavirus Cancer Monitoring Project between 12 March 2020 and 16 February 2021. Children who received stem cell transplantation were excluded. RESULTS: Only 2/62 patients with haematological malignancy had severe/critical infections, with an OR of 0.5 for patients with haematological compared with non-haematological malignancies. INTERPRETATION: Children with haematological malignancies are at no greater risk of severe SARS-CoV-2 infection than those with non-haematological malignancies. BMJ Publishing Group 2022-02 2021-07-22 /pmc/articles/PMC8785070/ /pubmed/34301621 http://dx.doi.org/10.1136/archdischild-2021-322062 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Report
Millen, Gerard Cathal
Arnold, Roland
Cazier, Jean-Baptiste
Curley, Helen
Feltbower, Richard
Gamble, Ashley
Glaser, Adam
Grundy, Richard G
Kirton, Laura
Lee, Lennard Y W
McCabe, Martin G
Palles, Claire
Phillips, Bob
Stiller, Charles A
Varnai, Csilla
Kearns, Pamela
COVID-19 in children with haematological malignancies
title COVID-19 in children with haematological malignancies
title_full COVID-19 in children with haematological malignancies
title_fullStr COVID-19 in children with haematological malignancies
title_full_unstemmed COVID-19 in children with haematological malignancies
title_short COVID-19 in children with haematological malignancies
title_sort covid-19 in children with haematological malignancies
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8785070/
https://www.ncbi.nlm.nih.gov/pubmed/34301621
http://dx.doi.org/10.1136/archdischild-2021-322062
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