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Disseminated histoplasmosis in an immunocompetent patient with COVID-19 pneumonia

Disseminated histoplasmosis is usually associated with immunosuppressive conditions like AIDS. People with respiratory distress syndrome secondary to SARS-CoV-2 pneumonia are vulnerable to bacterial infections. Additionally, coinfection with fungal pathogens should be considered as a differential di...

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Detalles Bibliográficos
Autores principales: Perez Del Nogal, Genesis, Mata, Andres, Ernest, Prince, Salinas, Ivania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8785166/
https://www.ncbi.nlm.nih.gov/pubmed/35064041
http://dx.doi.org/10.1136/bcr-2021-247617
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author Perez Del Nogal, Genesis
Mata, Andres
Ernest, Prince
Salinas, Ivania
author_facet Perez Del Nogal, Genesis
Mata, Andres
Ernest, Prince
Salinas, Ivania
author_sort Perez Del Nogal, Genesis
collection PubMed
description Disseminated histoplasmosis is usually associated with immunosuppressive conditions like AIDS. People with respiratory distress syndrome secondary to SARS-CoV-2 pneumonia are vulnerable to bacterial infections. Additionally, coinfection with fungal pathogens should be considered as a differential diagnosis even in immunocompetent patients who remain on mechanical ventilation secondary to COVID-19. The case presents a 61-year-old immunocompetent man, admitted to the medical ward due to COVID-19 pneumonia. Despite appropriate therapy, the patient required transfer to the intensive care unit for invasive mechanical ventilation. He remained critically ill with worsening respiratory failure. Two weeks later, coinfection by disseminated histoplasmosis was detected. After immediate treatment with amphotericin B and itraconazole, the patient tolerated weaning from mechanical ventilation until extubation. Awareness of this possible fungal coinfection in immunocompetent patients is essential to reduce delays in diagnosis and treatment, and prevent severe illness and death.
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spelling pubmed-87851662022-02-04 Disseminated histoplasmosis in an immunocompetent patient with COVID-19 pneumonia Perez Del Nogal, Genesis Mata, Andres Ernest, Prince Salinas, Ivania BMJ Case Rep Case Report Disseminated histoplasmosis is usually associated with immunosuppressive conditions like AIDS. People with respiratory distress syndrome secondary to SARS-CoV-2 pneumonia are vulnerable to bacterial infections. Additionally, coinfection with fungal pathogens should be considered as a differential diagnosis even in immunocompetent patients who remain on mechanical ventilation secondary to COVID-19. The case presents a 61-year-old immunocompetent man, admitted to the medical ward due to COVID-19 pneumonia. Despite appropriate therapy, the patient required transfer to the intensive care unit for invasive mechanical ventilation. He remained critically ill with worsening respiratory failure. Two weeks later, coinfection by disseminated histoplasmosis was detected. After immediate treatment with amphotericin B and itraconazole, the patient tolerated weaning from mechanical ventilation until extubation. Awareness of this possible fungal coinfection in immunocompetent patients is essential to reduce delays in diagnosis and treatment, and prevent severe illness and death. BMJ Publishing Group 2022-01-21 /pmc/articles/PMC8785166/ /pubmed/35064041 http://dx.doi.org/10.1136/bcr-2021-247617 Text en © BMJ Publishing Group Limited 2022. No commercial re-use. See rights and permissions. Published by BMJ. https://bmj.com/coronavirus/usageThis article is made freely available for personal use in accordance with BMJ’s website terms and conditions for the duration of the covid-19 pandemic or until otherwise determined by BMJ. You may use, download and print the article for any lawful, non-commercial purpose (including text and data mining) provided that all copyright notices and trade marks are retained.
spellingShingle Case Report
Perez Del Nogal, Genesis
Mata, Andres
Ernest, Prince
Salinas, Ivania
Disseminated histoplasmosis in an immunocompetent patient with COVID-19 pneumonia
title Disseminated histoplasmosis in an immunocompetent patient with COVID-19 pneumonia
title_full Disseminated histoplasmosis in an immunocompetent patient with COVID-19 pneumonia
title_fullStr Disseminated histoplasmosis in an immunocompetent patient with COVID-19 pneumonia
title_full_unstemmed Disseminated histoplasmosis in an immunocompetent patient with COVID-19 pneumonia
title_short Disseminated histoplasmosis in an immunocompetent patient with COVID-19 pneumonia
title_sort disseminated histoplasmosis in an immunocompetent patient with covid-19 pneumonia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8785166/
https://www.ncbi.nlm.nih.gov/pubmed/35064041
http://dx.doi.org/10.1136/bcr-2021-247617
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