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Coronavirus disease 2019 (Covid-19) outcomes in patients with sarcopenia: A meta-analysis and meta-regression

BACKGROUND: Sarcopenia has been associated with patients' poor quality of life, disability, and hospitalization. As of today, evidence that highlights the association between sarcopenia and Covid-19 outcomes remains unclear. This study sought to analyze whether patients with sarcopenia are at h...

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Autores principales: Siahaan, Yusak Mangara Tua, Hartoyo, Vinson, Hariyanto, Timotius Ivan, Kurniawan, Andree
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8785332/
https://www.ncbi.nlm.nih.gov/pubmed/35331486
http://dx.doi.org/10.1016/j.clnesp.2022.01.016
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author Siahaan, Yusak Mangara Tua
Hartoyo, Vinson
Hariyanto, Timotius Ivan
Kurniawan, Andree
author_facet Siahaan, Yusak Mangara Tua
Hartoyo, Vinson
Hariyanto, Timotius Ivan
Kurniawan, Andree
author_sort Siahaan, Yusak Mangara Tua
collection PubMed
description BACKGROUND: Sarcopenia has been associated with patients' poor quality of life, disability, and hospitalization. As of today, evidence that highlights the association between sarcopenia and Covid-19 outcomes remains unclear. This study sought to analyze whether patients with sarcopenia are at higher risk for developing poor Covid-19 outcomes. METHODS: Using specific keywords, we comprehensively go through the potential articles on medRxiv, Europe PMC, and PubMed sources until July 31st, 2021. All published studies on sarcopenia and coronavirus disease 2019 were collected. We were using Review Manager 5.4 and Comprehensive Meta-Analysis 3 software to conduct statistical analysis. RESULTS: There were 9 studies with 492,245 Covid-19 patients included in the analysis. Evaluation of the data gathered yielded an association between sarcopenia and increased severity of Covid-19 (OR 1.99; 95%CI: 1.37–2.90, p = 0.0003, I(2) = 79%, random-effect modelling); and mortality from Covid-19 (OR 1.96; 95%CI: 1.11–3.46, p = 0.020, I(2) = 49%, random-effect modelling). The increased risk of developing severe Covid-19 in a sarcopenic patient is also further influenced by cancer. CONCLUSIONS: This study proposes that patients with sarcopenia are at risk of developing poor Covid-19 outcomes. Patients with sarcopenia need special attention and should be prioritized to receive the SARS-CoV-2 vaccine. REGISTRATION DETAILS: PROSPERO (CRD42021270725).
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spelling pubmed-87853322022-01-25 Coronavirus disease 2019 (Covid-19) outcomes in patients with sarcopenia: A meta-analysis and meta-regression Siahaan, Yusak Mangara Tua Hartoyo, Vinson Hariyanto, Timotius Ivan Kurniawan, Andree Clin Nutr ESPEN Meta-Analysis BACKGROUND: Sarcopenia has been associated with patients' poor quality of life, disability, and hospitalization. As of today, evidence that highlights the association between sarcopenia and Covid-19 outcomes remains unclear. This study sought to analyze whether patients with sarcopenia are at higher risk for developing poor Covid-19 outcomes. METHODS: Using specific keywords, we comprehensively go through the potential articles on medRxiv, Europe PMC, and PubMed sources until July 31st, 2021. All published studies on sarcopenia and coronavirus disease 2019 were collected. We were using Review Manager 5.4 and Comprehensive Meta-Analysis 3 software to conduct statistical analysis. RESULTS: There were 9 studies with 492,245 Covid-19 patients included in the analysis. Evaluation of the data gathered yielded an association between sarcopenia and increased severity of Covid-19 (OR 1.99; 95%CI: 1.37–2.90, p = 0.0003, I(2) = 79%, random-effect modelling); and mortality from Covid-19 (OR 1.96; 95%CI: 1.11–3.46, p = 0.020, I(2) = 49%, random-effect modelling). The increased risk of developing severe Covid-19 in a sarcopenic patient is also further influenced by cancer. CONCLUSIONS: This study proposes that patients with sarcopenia are at risk of developing poor Covid-19 outcomes. Patients with sarcopenia need special attention and should be prioritized to receive the SARS-CoV-2 vaccine. REGISTRATION DETAILS: PROSPERO (CRD42021270725). European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. 2022-04 2022-01-24 /pmc/articles/PMC8785332/ /pubmed/35331486 http://dx.doi.org/10.1016/j.clnesp.2022.01.016 Text en © 2022 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Meta-Analysis
Siahaan, Yusak Mangara Tua
Hartoyo, Vinson
Hariyanto, Timotius Ivan
Kurniawan, Andree
Coronavirus disease 2019 (Covid-19) outcomes in patients with sarcopenia: A meta-analysis and meta-regression
title Coronavirus disease 2019 (Covid-19) outcomes in patients with sarcopenia: A meta-analysis and meta-regression
title_full Coronavirus disease 2019 (Covid-19) outcomes in patients with sarcopenia: A meta-analysis and meta-regression
title_fullStr Coronavirus disease 2019 (Covid-19) outcomes in patients with sarcopenia: A meta-analysis and meta-regression
title_full_unstemmed Coronavirus disease 2019 (Covid-19) outcomes in patients with sarcopenia: A meta-analysis and meta-regression
title_short Coronavirus disease 2019 (Covid-19) outcomes in patients with sarcopenia: A meta-analysis and meta-regression
title_sort coronavirus disease 2019 (covid-19) outcomes in patients with sarcopenia: a meta-analysis and meta-regression
topic Meta-Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8785332/
https://www.ncbi.nlm.nih.gov/pubmed/35331486
http://dx.doi.org/10.1016/j.clnesp.2022.01.016
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