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Mini Review: The Forensic Value of Heat Shock Proteins

Forensic pathologists are routinely confronted with unclear causes of death or related findings. In some instances, difficulties arise in relation to questions posed by criminal investigators or prosecutors. Such scenarios may include questions about wound vitality or cause of death where typical or...

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Autores principales: Prangenberg, Julian, Doberentz, Elke, Mawick, Anthea, Madea, Burkhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8785417/
https://www.ncbi.nlm.nih.gov/pubmed/35083250
http://dx.doi.org/10.3389/fmed.2021.800100
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author Prangenberg, Julian
Doberentz, Elke
Mawick, Anthea
Madea, Burkhard
author_facet Prangenberg, Julian
Doberentz, Elke
Mawick, Anthea
Madea, Burkhard
author_sort Prangenberg, Julian
collection PubMed
description Forensic pathologists are routinely confronted with unclear causes of death or related findings. In some instances, difficulties arise in relation to questions posed by criminal investigators or prosecutors. Such scenarios may include questions about wound vitality or cause of death where typical or landmark findings are difficult to ascertain. In addition to the usual examinations required to clarify unclear causes of death or address specific questions, immunohistochemistry and genetic analyses have become increasingly important techniques in this area since their establishment last century. Since then, many studies have determined the usefulness and significance of immunohistochemical and genetic investigations on cellular structures and proteins. For example, these proteins include heat shock proteins (Hsp), which were first described in 1962 and are so called based on their molecular weight. They predominantly act as molecular chaperones with cytoprotective functions that support cell survival under (sub) lethal conditions. They are expressed in specific cellular compartments and have many divergent functions. Central family members include, Hsp 27, 60, and 70. This mini review investigates recent research on the Hsp family, their application range, respective forensic importance, and current limitations and provides an outlook on possible applications within forensic science.
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spelling pubmed-87854172022-01-25 Mini Review: The Forensic Value of Heat Shock Proteins Prangenberg, Julian Doberentz, Elke Mawick, Anthea Madea, Burkhard Front Med (Lausanne) Medicine Forensic pathologists are routinely confronted with unclear causes of death or related findings. In some instances, difficulties arise in relation to questions posed by criminal investigators or prosecutors. Such scenarios may include questions about wound vitality or cause of death where typical or landmark findings are difficult to ascertain. In addition to the usual examinations required to clarify unclear causes of death or address specific questions, immunohistochemistry and genetic analyses have become increasingly important techniques in this area since their establishment last century. Since then, many studies have determined the usefulness and significance of immunohistochemical and genetic investigations on cellular structures and proteins. For example, these proteins include heat shock proteins (Hsp), which were first described in 1962 and are so called based on their molecular weight. They predominantly act as molecular chaperones with cytoprotective functions that support cell survival under (sub) lethal conditions. They are expressed in specific cellular compartments and have many divergent functions. Central family members include, Hsp 27, 60, and 70. This mini review investigates recent research on the Hsp family, their application range, respective forensic importance, and current limitations and provides an outlook on possible applications within forensic science. Frontiers Media S.A. 2022-01-10 /pmc/articles/PMC8785417/ /pubmed/35083250 http://dx.doi.org/10.3389/fmed.2021.800100 Text en Copyright © 2022 Prangenberg, Doberentz, Mawick and Madea. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Prangenberg, Julian
Doberentz, Elke
Mawick, Anthea
Madea, Burkhard
Mini Review: The Forensic Value of Heat Shock Proteins
title Mini Review: The Forensic Value of Heat Shock Proteins
title_full Mini Review: The Forensic Value of Heat Shock Proteins
title_fullStr Mini Review: The Forensic Value of Heat Shock Proteins
title_full_unstemmed Mini Review: The Forensic Value of Heat Shock Proteins
title_short Mini Review: The Forensic Value of Heat Shock Proteins
title_sort mini review: the forensic value of heat shock proteins
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8785417/
https://www.ncbi.nlm.nih.gov/pubmed/35083250
http://dx.doi.org/10.3389/fmed.2021.800100
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