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The importance of accessory protein variants in the pathogenicity of SARS-CoV-2
The coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS- CoV-2) with an estimated fatality rate of less than 1%. The SARS-CoV-2 accessory proteins ORF3a, ORF6, ORF7a, ORF7b, ORF8, and ORF10 possess putative functions to manipulate host immune me...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8785432/ https://www.ncbi.nlm.nih.gov/pubmed/35085577 http://dx.doi.org/10.1016/j.abb.2022.109124 |
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| author | Hassan, Sk. Sarif Choudhury, Pabitra Pal Dayhoff, Guy W. Aljabali, Alaa A.A. Uhal, Bruce D. Lundstrom, Kenneth Rezaei, Nima Pizzol, Damiano Adadi, Parise Lal, Amos Soares, Antonio Mohamed Abd El-Aziz, Tarek Brufsky, Adam M. Azad, Gajendra Kumar Sherchan, Samendra P. Baetas-da-Cruz, Wagner Takayama, Kazuo Serrano-Aroca, Ãngel Chauhan, Gaurav Palu, Giorgio Mishra, Yogendra Kumar Barh, Debmalya Santana Silva, Raner Jośe Andrade, Bruno Silva Azevedo, Vasco Góes-Neto, Aristóteles Bazan, Nicolas G. Redwan, Elrashdy M. Tambuwala, Murtaza Uversky, Vladimir N. |
| author_facet | Hassan, Sk. Sarif Choudhury, Pabitra Pal Dayhoff, Guy W. Aljabali, Alaa A.A. Uhal, Bruce D. Lundstrom, Kenneth Rezaei, Nima Pizzol, Damiano Adadi, Parise Lal, Amos Soares, Antonio Mohamed Abd El-Aziz, Tarek Brufsky, Adam M. Azad, Gajendra Kumar Sherchan, Samendra P. Baetas-da-Cruz, Wagner Takayama, Kazuo Serrano-Aroca, Ãngel Chauhan, Gaurav Palu, Giorgio Mishra, Yogendra Kumar Barh, Debmalya Santana Silva, Raner Jośe Andrade, Bruno Silva Azevedo, Vasco Góes-Neto, Aristóteles Bazan, Nicolas G. Redwan, Elrashdy M. Tambuwala, Murtaza Uversky, Vladimir N. |
| author_sort | Hassan, Sk. Sarif |
| collection | PubMed |
| description | The coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS- CoV-2) with an estimated fatality rate of less than 1%. The SARS-CoV-2 accessory proteins ORF3a, ORF6, ORF7a, ORF7b, ORF8, and ORF10 possess putative functions to manipulate host immune mechanisms. These involve interferons, which appear as a consensus function, immune signaling receptor NLRP3 (NLR family pyrin domain-containing 3) inflammasome, and inflammatory cytokines such as interleukin 1β (IL-1β) and are critical in COVID-19 pathology. Outspread variations of each of the six accessory proteins were observed across six continents of all complete SARS-CoV-2 proteomes based on the data reported before November 2020. A decreasing order of percentage of unique variations in the accessory proteins was determined as ORF3a > ORF8 > ORF7a > ORF6 > ORF10 > ORF7b across all continents. The highest and lowest unique variations of ORF3a were observed in South America and Oceania, respectively. These findings suggest that the wide variations in accessory proteins seem to affect the pathogenicity of SARS-CoV-2. |
| format | Online Article Text |
| id | pubmed-8785432 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Elsevier Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-87854322022-01-25 The importance of accessory protein variants in the pathogenicity of SARS-CoV-2 Hassan, Sk. Sarif Choudhury, Pabitra Pal Dayhoff, Guy W. Aljabali, Alaa A.A. Uhal, Bruce D. Lundstrom, Kenneth Rezaei, Nima Pizzol, Damiano Adadi, Parise Lal, Amos Soares, Antonio Mohamed Abd El-Aziz, Tarek Brufsky, Adam M. Azad, Gajendra Kumar Sherchan, Samendra P. Baetas-da-Cruz, Wagner Takayama, Kazuo Serrano-Aroca, Ãngel Chauhan, Gaurav Palu, Giorgio Mishra, Yogendra Kumar Barh, Debmalya Santana Silva, Raner Jośe Andrade, Bruno Silva Azevedo, Vasco Góes-Neto, Aristóteles Bazan, Nicolas G. Redwan, Elrashdy M. Tambuwala, Murtaza Uversky, Vladimir N. Arch Biochem Biophys Article The coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS- CoV-2) with an estimated fatality rate of less than 1%. The SARS-CoV-2 accessory proteins ORF3a, ORF6, ORF7a, ORF7b, ORF8, and ORF10 possess putative functions to manipulate host immune mechanisms. These involve interferons, which appear as a consensus function, immune signaling receptor NLRP3 (NLR family pyrin domain-containing 3) inflammasome, and inflammatory cytokines such as interleukin 1β (IL-1β) and are critical in COVID-19 pathology. Outspread variations of each of the six accessory proteins were observed across six continents of all complete SARS-CoV-2 proteomes based on the data reported before November 2020. A decreasing order of percentage of unique variations in the accessory proteins was determined as ORF3a > ORF8 > ORF7a > ORF6 > ORF10 > ORF7b across all continents. The highest and lowest unique variations of ORF3a were observed in South America and Oceania, respectively. These findings suggest that the wide variations in accessory proteins seem to affect the pathogenicity of SARS-CoV-2. Elsevier Inc. 2022-03-15 2022-01-24 /pmc/articles/PMC8785432/ /pubmed/35085577 http://dx.doi.org/10.1016/j.abb.2022.109124 Text en © 2022 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
| spellingShingle | Article Hassan, Sk. Sarif Choudhury, Pabitra Pal Dayhoff, Guy W. Aljabali, Alaa A.A. Uhal, Bruce D. Lundstrom, Kenneth Rezaei, Nima Pizzol, Damiano Adadi, Parise Lal, Amos Soares, Antonio Mohamed Abd El-Aziz, Tarek Brufsky, Adam M. Azad, Gajendra Kumar Sherchan, Samendra P. Baetas-da-Cruz, Wagner Takayama, Kazuo Serrano-Aroca, Ãngel Chauhan, Gaurav Palu, Giorgio Mishra, Yogendra Kumar Barh, Debmalya Santana Silva, Raner Jośe Andrade, Bruno Silva Azevedo, Vasco Góes-Neto, Aristóteles Bazan, Nicolas G. Redwan, Elrashdy M. Tambuwala, Murtaza Uversky, Vladimir N. The importance of accessory protein variants in the pathogenicity of SARS-CoV-2 |
| title | The importance of accessory protein variants in the pathogenicity of SARS-CoV-2 |
| title_full | The importance of accessory protein variants in the pathogenicity of SARS-CoV-2 |
| title_fullStr | The importance of accessory protein variants in the pathogenicity of SARS-CoV-2 |
| title_full_unstemmed | The importance of accessory protein variants in the pathogenicity of SARS-CoV-2 |
| title_short | The importance of accessory protein variants in the pathogenicity of SARS-CoV-2 |
| title_sort | importance of accessory protein variants in the pathogenicity of sars-cov-2 |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8785432/ https://www.ncbi.nlm.nih.gov/pubmed/35085577 http://dx.doi.org/10.1016/j.abb.2022.109124 |
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