Identification of two novel B-cell epitopes on the nucleocapsid protein of porcine deltacoronavirus

• Two monoclonal antibodies against newly emerged porcine deltacoronavirus nucleocapsid protein were prepared. • The epitopes that these two monoclonal antibodies recognized on nucleocapsid protein were identified. • The monoclonal antibody 6B7 recognized a linear epitope of N protein, while the 7F8...

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Detalles Bibliográficos
Autores principales: Ren, Haojie, Yan, Xiaoguang, Liu, Lintao, Zhang, Yixuan, Li, Qianqian, Li, Xiumei, Hu, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wuhan Institute of Virology, Chinese Academy of Sciences 2022
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8785457/
https://www.ncbi.nlm.nih.gov/pubmed/35307297
http://dx.doi.org/10.1016/j.virs.2022.01.025
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author Ren, Haojie
Yan, Xiaoguang
Liu, Lintao
Zhang, Yixuan
Li, Qianqian
Li, Xiumei
Hu, Hui
author_facet Ren, Haojie
Yan, Xiaoguang
Liu, Lintao
Zhang, Yixuan
Li, Qianqian
Li, Xiumei
Hu, Hui
author_sort Ren, Haojie
collection PubMed
description • Two monoclonal antibodies against newly emerged porcine deltacoronavirus nucleocapsid protein were prepared. • The epitopes that these two monoclonal antibodies recognized on nucleocapsid protein were identified. • The monoclonal antibody 6B7 recognized a linear epitope of N protein, while the 7F8 recognized a conformational epitope. • Conservation of the identified epitopes between different coronaviruses was analyzed.
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spelling pubmed-87854572022-01-25 Identification of two novel B-cell epitopes on the nucleocapsid protein of porcine deltacoronavirus Ren, Haojie Yan, Xiaoguang Liu, Lintao Zhang, Yixuan Li, Qianqian Li, Xiumei Hu, Hui Virol Sin Letter • Two monoclonal antibodies against newly emerged porcine deltacoronavirus nucleocapsid protein were prepared. • The epitopes that these two monoclonal antibodies recognized on nucleocapsid protein were identified. • The monoclonal antibody 6B7 recognized a linear epitope of N protein, while the 7F8 recognized a conformational epitope. • Conservation of the identified epitopes between different coronaviruses was analyzed. Wuhan Institute of Virology, Chinese Academy of Sciences 2022-01-24 /pmc/articles/PMC8785457/ /pubmed/35307297 http://dx.doi.org/10.1016/j.virs.2022.01.025 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Letter
Ren, Haojie
Yan, Xiaoguang
Liu, Lintao
Zhang, Yixuan
Li, Qianqian
Li, Xiumei
Hu, Hui
Identification of two novel B-cell epitopes on the nucleocapsid protein of porcine deltacoronavirus
title Identification of two novel B-cell epitopes on the nucleocapsid protein of porcine deltacoronavirus
title_full Identification of two novel B-cell epitopes on the nucleocapsid protein of porcine deltacoronavirus
title_fullStr Identification of two novel B-cell epitopes on the nucleocapsid protein of porcine deltacoronavirus
title_full_unstemmed Identification of two novel B-cell epitopes on the nucleocapsid protein of porcine deltacoronavirus
title_short Identification of two novel B-cell epitopes on the nucleocapsid protein of porcine deltacoronavirus
title_sort identification of two novel b-cell epitopes on the nucleocapsid protein of porcine deltacoronavirus
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8785457/
https://www.ncbi.nlm.nih.gov/pubmed/35307297
http://dx.doi.org/10.1016/j.virs.2022.01.025
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