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Serum concentration of zinc is elevated in clinically stable bipolar disorder patients
BACKGROUND: Bipolar disorder (BD) is a chronic psychiatric disorder characterized by recurrent mood episodes interspersed with euthymic periods. A growing number of studies have indicated that zinc plays an important role in coordinating immune responses, as well as being involved in synaptic transm...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8785612/ https://www.ncbi.nlm.nih.gov/pubmed/34967503 http://dx.doi.org/10.1002/brb3.2472 |
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author | Jonsson, Bo H. Orhan, Funda Bruno, Sanna Oliveira, Ana Osório Sparding, Timea Landen, Mikael Sellgren, Carl M. |
author_facet | Jonsson, Bo H. Orhan, Funda Bruno, Sanna Oliveira, Ana Osório Sparding, Timea Landen, Mikael Sellgren, Carl M. |
author_sort | Jonsson, Bo H. |
collection | PubMed |
description | BACKGROUND: Bipolar disorder (BD) is a chronic psychiatric disorder characterized by recurrent mood episodes interspersed with euthymic periods. A growing number of studies have indicated that zinc plays an important role in coordinating immune responses, as well as being involved in synaptic transmission. In the current study, we set out to measure serum levels of zinc in a meticulously phenotyped cohort of 121 euthymic BD subjects and 30 matched controls. METHODS: Serum levels of zinc were measured by photometry. To assess the interplay between zinc levels and immune activation in BD, we measured serum levels of high‐sensitive C‐reactive protein (hsCRP) levels by immunoturbidimetric assay, and serum levels of monocyte chemoattractant protein‐1 (MCP‐1), chitinase 3‐like protein 1 (YKL‐40), and soluble cluster of differentiation 14 (sCD14) by electrochemiluminescence enzyme‐linked immunosorbent assays. The baseline clinical diagnostic instrument for BD was the Affective Disorder Evaluation, and executive functioning was assessed by using the Delis–Kaplan Executive Function System. RESULTS: Controlling for potential confounding factors, BD patients displayed increased serum levels of zinc unrelated to hsCRP, MCP‐1, YKL‐40, and sCD14 levels. Serum levels of zinc did not associate with executive functioning or measurements of disease severity. DISCUSSION: This study suggests that the zinc homeostasis is disturbed in BD and that this dyshomeostasis is not related to ongoing mood symptoms or immune activation. Of note, serum levels were increased and hence do not support continuous zinc supplementation in BD. |
format | Online Article Text |
id | pubmed-8785612 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87856122022-01-31 Serum concentration of zinc is elevated in clinically stable bipolar disorder patients Jonsson, Bo H. Orhan, Funda Bruno, Sanna Oliveira, Ana Osório Sparding, Timea Landen, Mikael Sellgren, Carl M. Brain Behav Original Articles BACKGROUND: Bipolar disorder (BD) is a chronic psychiatric disorder characterized by recurrent mood episodes interspersed with euthymic periods. A growing number of studies have indicated that zinc plays an important role in coordinating immune responses, as well as being involved in synaptic transmission. In the current study, we set out to measure serum levels of zinc in a meticulously phenotyped cohort of 121 euthymic BD subjects and 30 matched controls. METHODS: Serum levels of zinc were measured by photometry. To assess the interplay between zinc levels and immune activation in BD, we measured serum levels of high‐sensitive C‐reactive protein (hsCRP) levels by immunoturbidimetric assay, and serum levels of monocyte chemoattractant protein‐1 (MCP‐1), chitinase 3‐like protein 1 (YKL‐40), and soluble cluster of differentiation 14 (sCD14) by electrochemiluminescence enzyme‐linked immunosorbent assays. The baseline clinical diagnostic instrument for BD was the Affective Disorder Evaluation, and executive functioning was assessed by using the Delis–Kaplan Executive Function System. RESULTS: Controlling for potential confounding factors, BD patients displayed increased serum levels of zinc unrelated to hsCRP, MCP‐1, YKL‐40, and sCD14 levels. Serum levels of zinc did not associate with executive functioning or measurements of disease severity. DISCUSSION: This study suggests that the zinc homeostasis is disturbed in BD and that this dyshomeostasis is not related to ongoing mood symptoms or immune activation. Of note, serum levels were increased and hence do not support continuous zinc supplementation in BD. John Wiley and Sons Inc. 2021-12-30 /pmc/articles/PMC8785612/ /pubmed/34967503 http://dx.doi.org/10.1002/brb3.2472 Text en © 2021 The Authors. Brain and Behavior published by Wiley Periodicals LLC https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Jonsson, Bo H. Orhan, Funda Bruno, Sanna Oliveira, Ana Osório Sparding, Timea Landen, Mikael Sellgren, Carl M. Serum concentration of zinc is elevated in clinically stable bipolar disorder patients |
title | Serum concentration of zinc is elevated in clinically stable bipolar disorder patients |
title_full | Serum concentration of zinc is elevated in clinically stable bipolar disorder patients |
title_fullStr | Serum concentration of zinc is elevated in clinically stable bipolar disorder patients |
title_full_unstemmed | Serum concentration of zinc is elevated in clinically stable bipolar disorder patients |
title_short | Serum concentration of zinc is elevated in clinically stable bipolar disorder patients |
title_sort | serum concentration of zinc is elevated in clinically stable bipolar disorder patients |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8785612/ https://www.ncbi.nlm.nih.gov/pubmed/34967503 http://dx.doi.org/10.1002/brb3.2472 |
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