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Genetic effects on educational attainment in Hungary

INTRODUCTION: Educational attainment is a substantially heritable trait, and it has recently been linked to specific genetic variants by genome‐wide association studies (GWASs). However, the effects of such genetic variants are expected to vary across environments, including countries and historical...

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Autores principales: Ujma, Péter P., Eszlári, Nóra, Millinghoffer, András, Bruncsics, Bence, Török, Dóra, Petschner, Péter, Antal, Péter, Deakin, Bill, Breen, Gerome, Bagdy, György, Juhász, Gabriella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8785634/
https://www.ncbi.nlm.nih.gov/pubmed/34843176
http://dx.doi.org/10.1002/brb3.2430
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author Ujma, Péter P.
Eszlári, Nóra
Millinghoffer, András
Bruncsics, Bence
Török, Dóra
Petschner, Péter
Antal, Péter
Deakin, Bill
Breen, Gerome
Bagdy, György
Juhász, Gabriella
author_facet Ujma, Péter P.
Eszlári, Nóra
Millinghoffer, András
Bruncsics, Bence
Török, Dóra
Petschner, Péter
Antal, Péter
Deakin, Bill
Breen, Gerome
Bagdy, György
Juhász, Gabriella
author_sort Ujma, Péter P.
collection PubMed
description INTRODUCTION: Educational attainment is a substantially heritable trait, and it has recently been linked to specific genetic variants by genome‐wide association studies (GWASs). However, the effects of such genetic variants are expected to vary across environments, including countries and historical eras. METHODS: We used polygenic scores (PGSs) to assess molecular genetic effects on educational attainment in Hungary, a country in the Central Eastern European region where behavioral genetic studies are in general scarce and molecular genetic studies of educational attainment have not been previously published. RESULTS: We found that the PGS is significantly associated with the attainment of a college degree as well as the number of years in education in a sample of Hungarian study participants (N = 829). PGS effect sizes were not significantly different when compared to an English (N = 976) comparison sample with identical measurement protocols. In line with previous Estonian findings, we found higher PGS effect sizes in Hungarian, but not in English participants who attended higher education after the fall of Communism, although we lacked statistical power for this effect to reach significance. DISCUSSION: Our results provide evidence that polygenic scores for educational attainment have predictive value in culturally diverse European populations.
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spelling pubmed-87856342022-01-31 Genetic effects on educational attainment in Hungary Ujma, Péter P. Eszlári, Nóra Millinghoffer, András Bruncsics, Bence Török, Dóra Petschner, Péter Antal, Péter Deakin, Bill Breen, Gerome Bagdy, György Juhász, Gabriella Brain Behav Original Articles INTRODUCTION: Educational attainment is a substantially heritable trait, and it has recently been linked to specific genetic variants by genome‐wide association studies (GWASs). However, the effects of such genetic variants are expected to vary across environments, including countries and historical eras. METHODS: We used polygenic scores (PGSs) to assess molecular genetic effects on educational attainment in Hungary, a country in the Central Eastern European region where behavioral genetic studies are in general scarce and molecular genetic studies of educational attainment have not been previously published. RESULTS: We found that the PGS is significantly associated with the attainment of a college degree as well as the number of years in education in a sample of Hungarian study participants (N = 829). PGS effect sizes were not significantly different when compared to an English (N = 976) comparison sample with identical measurement protocols. In line with previous Estonian findings, we found higher PGS effect sizes in Hungarian, but not in English participants who attended higher education after the fall of Communism, although we lacked statistical power for this effect to reach significance. DISCUSSION: Our results provide evidence that polygenic scores for educational attainment have predictive value in culturally diverse European populations. John Wiley and Sons Inc. 2021-11-29 /pmc/articles/PMC8785634/ /pubmed/34843176 http://dx.doi.org/10.1002/brb3.2430 Text en © 2021 The Authors. Brain and Behavior published by Wiley Periodicals LLC https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Ujma, Péter P.
Eszlári, Nóra
Millinghoffer, András
Bruncsics, Bence
Török, Dóra
Petschner, Péter
Antal, Péter
Deakin, Bill
Breen, Gerome
Bagdy, György
Juhász, Gabriella
Genetic effects on educational attainment in Hungary
title Genetic effects on educational attainment in Hungary
title_full Genetic effects on educational attainment in Hungary
title_fullStr Genetic effects on educational attainment in Hungary
title_full_unstemmed Genetic effects on educational attainment in Hungary
title_short Genetic effects on educational attainment in Hungary
title_sort genetic effects on educational attainment in hungary
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8785634/
https://www.ncbi.nlm.nih.gov/pubmed/34843176
http://dx.doi.org/10.1002/brb3.2430
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