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SARS-CoV-2 and endemic coronaviruses: Comparing symptom presentation and severity of symptomatic illness among Nicaraguan children

It has been proposed that as SARS-CoV-2 transitions to endemicity, children will represent the greatest proportion of SARS-Co-V-2 infections as they currently do with endemic coronavirus infections. While SARS-CoV-2 infection severity is low for children, it is unclear if SARS-CoV-2 infections are d...

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Autores principales: Frutos, Aaron M, Kubale, John, Kuan, Guillermina, Ojeda, Sergio, Vydiswaran, Nivea, Sanchez, Nery, Plazaola, Miguel, Patel, May, Lopez, Roger, Balmaseda, Angel, Gordon, Aubree
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786229/
https://www.ncbi.nlm.nih.gov/pubmed/35075460
http://dx.doi.org/10.1101/2021.12.09.21267537
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author Frutos, Aaron M
Kubale, John
Kuan, Guillermina
Ojeda, Sergio
Vydiswaran, Nivea
Sanchez, Nery
Plazaola, Miguel
Patel, May
Lopez, Roger
Balmaseda, Angel
Gordon, Aubree
author_facet Frutos, Aaron M
Kubale, John
Kuan, Guillermina
Ojeda, Sergio
Vydiswaran, Nivea
Sanchez, Nery
Plazaola, Miguel
Patel, May
Lopez, Roger
Balmaseda, Angel
Gordon, Aubree
author_sort Frutos, Aaron M
collection PubMed
description It has been proposed that as SARS-CoV-2 transitions to endemicity, children will represent the greatest proportion of SARS-Co-V-2 infections as they currently do with endemic coronavirus infections. While SARS-CoV-2 infection severity is low for children, it is unclear if SARS-CoV-2 infections are distinct in symptom presentation, duration, and severity from endemic coronavirus infections in children. We compared symptom risk and duration of endemic human coronavirus (HCoV) infections from 2011–2016 with SARS-CoV-2 infections from March 2020-September 2021 in a Nicaraguan pediatric cohort. Blood samples were collected from study participants annually in February-April. Respiratory samples were collected from participants that met testing criteria. Blood samples collected in were tested for SARS-CoV-2 antibodies and a subset of 2011–2016 blood samples from four-year-old children were tested for endemic HCoV antibodies. Respiratory samples were tested for each of the endemic HCoVs from 2011–2016 and for SARS-CoV-2 from 2020–2021 via rt-PCR. By April 2021, 854 (49%) cohort participants were ELISA positive for SARS-CoV-2 antibodies. Most participants had antibodies against one alpha and one beta coronavirus by age four. We observed 595 symptomatic endemic HCoV infections from 2011–2016 and 121 symptomatic with SARS-CoV-2 infections from March 2020-September 2021. Symptom presentation of SARS-CoV-2 infection and endemic coronavirus infections were very similar, and SARS-CoV-2 symptomatic infections were as or less severe on average than endemic HCoV infections. This suggests that, for children, SARS-CoV-2 may be just another endemic coronavirus. However, questions about the impact of variants and the long-term effects of SARS-CoV-2 remain.
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spelling pubmed-87862292022-01-25 SARS-CoV-2 and endemic coronaviruses: Comparing symptom presentation and severity of symptomatic illness among Nicaraguan children Frutos, Aaron M Kubale, John Kuan, Guillermina Ojeda, Sergio Vydiswaran, Nivea Sanchez, Nery Plazaola, Miguel Patel, May Lopez, Roger Balmaseda, Angel Gordon, Aubree medRxiv Article It has been proposed that as SARS-CoV-2 transitions to endemicity, children will represent the greatest proportion of SARS-Co-V-2 infections as they currently do with endemic coronavirus infections. While SARS-CoV-2 infection severity is low for children, it is unclear if SARS-CoV-2 infections are distinct in symptom presentation, duration, and severity from endemic coronavirus infections in children. We compared symptom risk and duration of endemic human coronavirus (HCoV) infections from 2011–2016 with SARS-CoV-2 infections from March 2020-September 2021 in a Nicaraguan pediatric cohort. Blood samples were collected from study participants annually in February-April. Respiratory samples were collected from participants that met testing criteria. Blood samples collected in were tested for SARS-CoV-2 antibodies and a subset of 2011–2016 blood samples from four-year-old children were tested for endemic HCoV antibodies. Respiratory samples were tested for each of the endemic HCoVs from 2011–2016 and for SARS-CoV-2 from 2020–2021 via rt-PCR. By April 2021, 854 (49%) cohort participants were ELISA positive for SARS-CoV-2 antibodies. Most participants had antibodies against one alpha and one beta coronavirus by age four. We observed 595 symptomatic endemic HCoV infections from 2011–2016 and 121 symptomatic with SARS-CoV-2 infections from March 2020-September 2021. Symptom presentation of SARS-CoV-2 infection and endemic coronavirus infections were very similar, and SARS-CoV-2 symptomatic infections were as or less severe on average than endemic HCoV infections. This suggests that, for children, SARS-CoV-2 may be just another endemic coronavirus. However, questions about the impact of variants and the long-term effects of SARS-CoV-2 remain. Cold Spring Harbor Laboratory 2022-02-03 /pmc/articles/PMC8786229/ /pubmed/35075460 http://dx.doi.org/10.1101/2021.12.09.21267537 Text en https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Frutos, Aaron M
Kubale, John
Kuan, Guillermina
Ojeda, Sergio
Vydiswaran, Nivea
Sanchez, Nery
Plazaola, Miguel
Patel, May
Lopez, Roger
Balmaseda, Angel
Gordon, Aubree
SARS-CoV-2 and endemic coronaviruses: Comparing symptom presentation and severity of symptomatic illness among Nicaraguan children
title SARS-CoV-2 and endemic coronaviruses: Comparing symptom presentation and severity of symptomatic illness among Nicaraguan children
title_full SARS-CoV-2 and endemic coronaviruses: Comparing symptom presentation and severity of symptomatic illness among Nicaraguan children
title_fullStr SARS-CoV-2 and endemic coronaviruses: Comparing symptom presentation and severity of symptomatic illness among Nicaraguan children
title_full_unstemmed SARS-CoV-2 and endemic coronaviruses: Comparing symptom presentation and severity of symptomatic illness among Nicaraguan children
title_short SARS-CoV-2 and endemic coronaviruses: Comparing symptom presentation and severity of symptomatic illness among Nicaraguan children
title_sort sars-cov-2 and endemic coronaviruses: comparing symptom presentation and severity of symptomatic illness among nicaraguan children
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786229/
https://www.ncbi.nlm.nih.gov/pubmed/35075460
http://dx.doi.org/10.1101/2021.12.09.21267537
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