First studies on tumor associated carbonic anhydrases IX and XII monoclonal antibodies conjugated to small molecule inhibitors

We report for the first time Antibody-Drug-Conjugates (ADCs) containing human (h) Carbonic Anhydrase (CA; EC 4.2.1.1) directed Monoclonal Antibodies (MAbs) linked to low molecular weight inhibitors of the same enzymes by means of hydrophilic peptide spacers. In agreement with the incorporated CA dir...

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Detalles Bibliográficos
Autores principales: Testa, Chiara, Papini, Anna Maria, Zeidler, Reinhard, Vullo, Daniela, Carta, Fabrizio, Supuran, Claudiu T., Rovero, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786240/
https://www.ncbi.nlm.nih.gov/pubmed/35057692
http://dx.doi.org/10.1080/14756366.2021.2004593

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786240/
https://www.ncbi.nlm.nih.gov/pubmed/35057692
http://dx.doi.org/10.1080/14756366.2021.2004593

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