Maintaining mitochondrial ribosome function: The role of ribosome rescue and recycling factors
The universally conserved process of protein biosynthesis is crucial for maintaining cellular homoeostasis and in eukaryotes, mitochondrial translation is essential for aerobic energy production. Mitochondrial ribosomes (mitoribosomes) are highly specialized to synthesize 13 core subunits of the oxi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786322/ https://www.ncbi.nlm.nih.gov/pubmed/34923906 http://dx.doi.org/10.1080/15476286.2021.2015561 |
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author | Nadler, Franziska Lavdovskaia, Elena Richter-Dennerlein, Ricarda |
author_facet | Nadler, Franziska Lavdovskaia, Elena Richter-Dennerlein, Ricarda |
author_sort | Nadler, Franziska |
collection | PubMed |
description | The universally conserved process of protein biosynthesis is crucial for maintaining cellular homoeostasis and in eukaryotes, mitochondrial translation is essential for aerobic energy production. Mitochondrial ribosomes (mitoribosomes) are highly specialized to synthesize 13 core subunits of the oxidative phosphorylation (OXPHOS) complexes. Although the mitochondrial translation machinery traces its origin from a bacterial ancestor, it has acquired substantial differences within this endosymbiotic environment. The cycle of mitoribosome function proceeds through the conserved canonical steps of initiation, elongation, termination and mitoribosome recycling. However, when mitoribosomes operate in the context of limited translation factors or on aberrant mRNAs, they can become stalled and activation of rescue mechanisms is required. This review summarizes recent advances in the understanding of protein biosynthesis in mitochondria, focusing especially on the mechanistic and physiological details of translation termination, and mitoribosome recycling and rescue. |
format | Online Article Text |
id | pubmed-8786322 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-87863222022-01-25 Maintaining mitochondrial ribosome function: The role of ribosome rescue and recycling factors Nadler, Franziska Lavdovskaia, Elena Richter-Dennerlein, Ricarda RNA Biol Review The universally conserved process of protein biosynthesis is crucial for maintaining cellular homoeostasis and in eukaryotes, mitochondrial translation is essential for aerobic energy production. Mitochondrial ribosomes (mitoribosomes) are highly specialized to synthesize 13 core subunits of the oxidative phosphorylation (OXPHOS) complexes. Although the mitochondrial translation machinery traces its origin from a bacterial ancestor, it has acquired substantial differences within this endosymbiotic environment. The cycle of mitoribosome function proceeds through the conserved canonical steps of initiation, elongation, termination and mitoribosome recycling. However, when mitoribosomes operate in the context of limited translation factors or on aberrant mRNAs, they can become stalled and activation of rescue mechanisms is required. This review summarizes recent advances in the understanding of protein biosynthesis in mitochondria, focusing especially on the mechanistic and physiological details of translation termination, and mitoribosome recycling and rescue. Taylor & Francis 2021-12-20 /pmc/articles/PMC8786322/ /pubmed/34923906 http://dx.doi.org/10.1080/15476286.2021.2015561 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Nadler, Franziska Lavdovskaia, Elena Richter-Dennerlein, Ricarda Maintaining mitochondrial ribosome function: The role of ribosome rescue and recycling factors |
title | Maintaining mitochondrial ribosome function: The role of ribosome rescue and recycling factors |
title_full | Maintaining mitochondrial ribosome function: The role of ribosome rescue and recycling factors |
title_fullStr | Maintaining mitochondrial ribosome function: The role of ribosome rescue and recycling factors |
title_full_unstemmed | Maintaining mitochondrial ribosome function: The role of ribosome rescue and recycling factors |
title_short | Maintaining mitochondrial ribosome function: The role of ribosome rescue and recycling factors |
title_sort | maintaining mitochondrial ribosome function: the role of ribosome rescue and recycling factors |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786322/ https://www.ncbi.nlm.nih.gov/pubmed/34923906 http://dx.doi.org/10.1080/15476286.2021.2015561 |
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