Identification of HnRNPC as a novel Tau exon 10 splicing factor using RNA antisense purification mass spectrometry

Alternative splicing in Tau exon 10 generates 3 R- and 4 R-Tau proteoforms, which have equal abundance in healthy adult human brain. Aberrant alternative splicing in Tau exon 10 leads to distortion of the balanced 3 R- and 4 R-Tau expression levels, which is a causal factor to trigger toxic Tau aggr...

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Detalles Bibliográficos
Autores principales: Xing, Sansi, Wang, Jane, Wu, Ruilin, Hefti, Marco M., Crary, John F., Lu, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786334/
https://www.ncbi.nlm.nih.gov/pubmed/34965173
http://dx.doi.org/10.1080/15476286.2021.2015175

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786334/
https://www.ncbi.nlm.nih.gov/pubmed/34965173
http://dx.doi.org/10.1080/15476286.2021.2015175

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