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Adipose endothelial cells mastering adipose tissues metabolic fate

Dynamic communication within adipose tissue depends on highly vascularized structural characteristics to maintain systemic metabolic homoeostasis. Recently, it has been noted that adipose endothelial cells (AdECs) act as essential bridges for biological information transmission between adipose-resid...

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Detalles Bibliográficos
Autores principales: Liao, Zhe-Zhen, Ran, Li, Qi, Xiao-Yan, Wang, Ya-Di, Wang, Yuan-Yuan, Yang, Jing, Liu, Jiang-Hua, Xiao, Xin-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786343/
https://www.ncbi.nlm.nih.gov/pubmed/35067158
http://dx.doi.org/10.1080/21623945.2022.2028372
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author Liao, Zhe-Zhen
Ran, Li
Qi, Xiao-Yan
Wang, Ya-Di
Wang, Yuan-Yuan
Yang, Jing
Liu, Jiang-Hua
Xiao, Xin-Hua
author_facet Liao, Zhe-Zhen
Ran, Li
Qi, Xiao-Yan
Wang, Ya-Di
Wang, Yuan-Yuan
Yang, Jing
Liu, Jiang-Hua
Xiao, Xin-Hua
author_sort Liao, Zhe-Zhen
collection PubMed
description Dynamic communication within adipose tissue depends on highly vascularized structural characteristics to maintain systemic metabolic homoeostasis. Recently, it has been noted that adipose endothelial cells (AdECs) act as essential bridges for biological information transmission between adipose-resident cells. Hence, paracrine regulators that mediate crosstalk between AdECs and adipose stromal cells were summarized. We also highlight the importance of AdECs to maintain adipocytes metabolic homoeostasis by regulating insulin sensitivity, lipid turnover and plasticity. The differential regulation of AdECs in adipose plasticity often depends on vascular density and metabolic states. Although choosing pro-angiogenic or anti-angiogenic therapies for obesity is still a matter of debate in clinical settings, the growing numbers of drugs have been confirmed to play an anti-obesity effect by affecting vascularization. Pharmacologic angiogenesis intervention has great potential as therapeutic strategies for obesity.
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spelling pubmed-87863432022-01-25 Adipose endothelial cells mastering adipose tissues metabolic fate Liao, Zhe-Zhen Ran, Li Qi, Xiao-Yan Wang, Ya-Di Wang, Yuan-Yuan Yang, Jing Liu, Jiang-Hua Xiao, Xin-Hua Adipocyte Review Dynamic communication within adipose tissue depends on highly vascularized structural characteristics to maintain systemic metabolic homoeostasis. Recently, it has been noted that adipose endothelial cells (AdECs) act as essential bridges for biological information transmission between adipose-resident cells. Hence, paracrine regulators that mediate crosstalk between AdECs and adipose stromal cells were summarized. We also highlight the importance of AdECs to maintain adipocytes metabolic homoeostasis by regulating insulin sensitivity, lipid turnover and plasticity. The differential regulation of AdECs in adipose plasticity often depends on vascular density and metabolic states. Although choosing pro-angiogenic or anti-angiogenic therapies for obesity is still a matter of debate in clinical settings, the growing numbers of drugs have been confirmed to play an anti-obesity effect by affecting vascularization. Pharmacologic angiogenesis intervention has great potential as therapeutic strategies for obesity. Taylor & Francis 2022-01-22 /pmc/articles/PMC8786343/ /pubmed/35067158 http://dx.doi.org/10.1080/21623945.2022.2028372 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Liao, Zhe-Zhen
Ran, Li
Qi, Xiao-Yan
Wang, Ya-Di
Wang, Yuan-Yuan
Yang, Jing
Liu, Jiang-Hua
Xiao, Xin-Hua
Adipose endothelial cells mastering adipose tissues metabolic fate
title Adipose endothelial cells mastering adipose tissues metabolic fate
title_full Adipose endothelial cells mastering adipose tissues metabolic fate
title_fullStr Adipose endothelial cells mastering adipose tissues metabolic fate
title_full_unstemmed Adipose endothelial cells mastering adipose tissues metabolic fate
title_short Adipose endothelial cells mastering adipose tissues metabolic fate
title_sort adipose endothelial cells mastering adipose tissues metabolic fate
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786343/
https://www.ncbi.nlm.nih.gov/pubmed/35067158
http://dx.doi.org/10.1080/21623945.2022.2028372
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