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Adipose endothelial cells mastering adipose tissues metabolic fate
Dynamic communication within adipose tissue depends on highly vascularized structural characteristics to maintain systemic metabolic homoeostasis. Recently, it has been noted that adipose endothelial cells (AdECs) act as essential bridges for biological information transmission between adipose-resid...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786343/ https://www.ncbi.nlm.nih.gov/pubmed/35067158 http://dx.doi.org/10.1080/21623945.2022.2028372 |
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author | Liao, Zhe-Zhen Ran, Li Qi, Xiao-Yan Wang, Ya-Di Wang, Yuan-Yuan Yang, Jing Liu, Jiang-Hua Xiao, Xin-Hua |
author_facet | Liao, Zhe-Zhen Ran, Li Qi, Xiao-Yan Wang, Ya-Di Wang, Yuan-Yuan Yang, Jing Liu, Jiang-Hua Xiao, Xin-Hua |
author_sort | Liao, Zhe-Zhen |
collection | PubMed |
description | Dynamic communication within adipose tissue depends on highly vascularized structural characteristics to maintain systemic metabolic homoeostasis. Recently, it has been noted that adipose endothelial cells (AdECs) act as essential bridges for biological information transmission between adipose-resident cells. Hence, paracrine regulators that mediate crosstalk between AdECs and adipose stromal cells were summarized. We also highlight the importance of AdECs to maintain adipocytes metabolic homoeostasis by regulating insulin sensitivity, lipid turnover and plasticity. The differential regulation of AdECs in adipose plasticity often depends on vascular density and metabolic states. Although choosing pro-angiogenic or anti-angiogenic therapies for obesity is still a matter of debate in clinical settings, the growing numbers of drugs have been confirmed to play an anti-obesity effect by affecting vascularization. Pharmacologic angiogenesis intervention has great potential as therapeutic strategies for obesity. |
format | Online Article Text |
id | pubmed-8786343 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-87863432022-01-25 Adipose endothelial cells mastering adipose tissues metabolic fate Liao, Zhe-Zhen Ran, Li Qi, Xiao-Yan Wang, Ya-Di Wang, Yuan-Yuan Yang, Jing Liu, Jiang-Hua Xiao, Xin-Hua Adipocyte Review Dynamic communication within adipose tissue depends on highly vascularized structural characteristics to maintain systemic metabolic homoeostasis. Recently, it has been noted that adipose endothelial cells (AdECs) act as essential bridges for biological information transmission between adipose-resident cells. Hence, paracrine regulators that mediate crosstalk between AdECs and adipose stromal cells were summarized. We also highlight the importance of AdECs to maintain adipocytes metabolic homoeostasis by regulating insulin sensitivity, lipid turnover and plasticity. The differential regulation of AdECs in adipose plasticity often depends on vascular density and metabolic states. Although choosing pro-angiogenic or anti-angiogenic therapies for obesity is still a matter of debate in clinical settings, the growing numbers of drugs have been confirmed to play an anti-obesity effect by affecting vascularization. Pharmacologic angiogenesis intervention has great potential as therapeutic strategies for obesity. Taylor & Francis 2022-01-22 /pmc/articles/PMC8786343/ /pubmed/35067158 http://dx.doi.org/10.1080/21623945.2022.2028372 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Liao, Zhe-Zhen Ran, Li Qi, Xiao-Yan Wang, Ya-Di Wang, Yuan-Yuan Yang, Jing Liu, Jiang-Hua Xiao, Xin-Hua Adipose endothelial cells mastering adipose tissues metabolic fate |
title | Adipose endothelial cells mastering adipose tissues metabolic fate |
title_full | Adipose endothelial cells mastering adipose tissues metabolic fate |
title_fullStr | Adipose endothelial cells mastering adipose tissues metabolic fate |
title_full_unstemmed | Adipose endothelial cells mastering adipose tissues metabolic fate |
title_short | Adipose endothelial cells mastering adipose tissues metabolic fate |
title_sort | adipose endothelial cells mastering adipose tissues metabolic fate |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786343/ https://www.ncbi.nlm.nih.gov/pubmed/35067158 http://dx.doi.org/10.1080/21623945.2022.2028372 |
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