Activation of Transcription Factor EB Alleviates Tubular Epithelial Cell Injury via Restoring Lysosomal Homeostasis in Diabetic Nephropathy

Disruption of lysosomal homeostasis contributes to the tubulopathy of diabetic nephropathy; however, its underlying mechanisms remain unclear. Herein, we report that decreased activity of transcription factor EB (TFEB) is responsible for the disturbed lysosome biogenesis and clearance in this pathol...

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Detalles Bibliográficos
Autores principales: Wang, Shujun, Jing, Kaipeng, Wu, Hongluan, Li, Xiaoyu, Yang, Chen, Li, Tingting, Tang, Haoxuan, Zou, Ting, She, Yao, Liu, Hua-feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786470/
https://www.ncbi.nlm.nih.gov/pubmed/35082964
http://dx.doi.org/10.1155/2022/2812493

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786470/
https://www.ncbi.nlm.nih.gov/pubmed/35082964
http://dx.doi.org/10.1155/2022/2812493

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