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Study on the Mechanism of Fentanyl in Pain Treatment Based on Network Pharmacology
This is a study that is based on network pharmacology, focusing on the pharmacological mechanism of fentanyl in easing pain. Through PPI, GO, and KEGG network pharmacology, the potential pharmacological mechanism of fentanyl was studied. This study compared and analyzed the overlap between the targe...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786484/ https://www.ncbi.nlm.nih.gov/pubmed/35083024 http://dx.doi.org/10.1155/2022/4139200 |
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author | Zhou, Shuqin Bi, Juan Zhao, Wei Zhao, Jian Wan, Honghong Wang, Sheng |
author_facet | Zhou, Shuqin Bi, Juan Zhao, Wei Zhao, Jian Wan, Honghong Wang, Sheng |
author_sort | Zhou, Shuqin |
collection | PubMed |
description | This is a study that is based on network pharmacology, focusing on the pharmacological mechanism of fentanyl in easing pain. Through PPI, GO, and KEGG network pharmacology, the potential pharmacological mechanism of fentanyl was studied. This study compared and analyzed the overlap between the target genes of the active ingredient of fentanyl and the pain treatment target genes. After constructing PPI based on fentanyl, the GO and KEDD pathways were analyzed for enrichment. On the basis of overlapping genes, we constructed the PPI, GO, and KEGG, and analysis showed that the mechanism was likely to be related to some biological process. This study preliminarily identified the important proteins and metabolic pathways related to fentanyl in pain treatment and expected to provide new evidence and research ideas for the use of fentanyl, enhancing effects and alleviating adverse drug reactions. |
format | Online Article Text |
id | pubmed-8786484 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-87864842022-01-25 Study on the Mechanism of Fentanyl in Pain Treatment Based on Network Pharmacology Zhou, Shuqin Bi, Juan Zhao, Wei Zhao, Jian Wan, Honghong Wang, Sheng J Healthc Eng Research Article This is a study that is based on network pharmacology, focusing on the pharmacological mechanism of fentanyl in easing pain. Through PPI, GO, and KEGG network pharmacology, the potential pharmacological mechanism of fentanyl was studied. This study compared and analyzed the overlap between the target genes of the active ingredient of fentanyl and the pain treatment target genes. After constructing PPI based on fentanyl, the GO and KEDD pathways were analyzed for enrichment. On the basis of overlapping genes, we constructed the PPI, GO, and KEGG, and analysis showed that the mechanism was likely to be related to some biological process. This study preliminarily identified the important proteins and metabolic pathways related to fentanyl in pain treatment and expected to provide new evidence and research ideas for the use of fentanyl, enhancing effects and alleviating adverse drug reactions. Hindawi 2022-01-17 /pmc/articles/PMC8786484/ /pubmed/35083024 http://dx.doi.org/10.1155/2022/4139200 Text en Copyright © 2022 Shuqin Zhou et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zhou, Shuqin Bi, Juan Zhao, Wei Zhao, Jian Wan, Honghong Wang, Sheng Study on the Mechanism of Fentanyl in Pain Treatment Based on Network Pharmacology |
title | Study on the Mechanism of Fentanyl in Pain Treatment Based on Network Pharmacology |
title_full | Study on the Mechanism of Fentanyl in Pain Treatment Based on Network Pharmacology |
title_fullStr | Study on the Mechanism of Fentanyl in Pain Treatment Based on Network Pharmacology |
title_full_unstemmed | Study on the Mechanism of Fentanyl in Pain Treatment Based on Network Pharmacology |
title_short | Study on the Mechanism of Fentanyl in Pain Treatment Based on Network Pharmacology |
title_sort | study on the mechanism of fentanyl in pain treatment based on network pharmacology |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786484/ https://www.ncbi.nlm.nih.gov/pubmed/35083024 http://dx.doi.org/10.1155/2022/4139200 |
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