Prognostic Role of Tumor Microenvironment in DLBCL and Relation to Patients' Clinical Outcome: A Clinical and Immunohistochemical Study

Diffuse large B cell lymphoma is the most common type of lymphoma in Egypt with an unfavorable prognosis. The tumor microenvironment is rich in immune response either T cells or macrophages. The current study is aimed at testing CD4, CD8, CD68, and MMP9 immunohistochemistry of DLBCL activities with...

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Autores principales: Ghorab, Doaa Shams-Deen, Helaly, Ahmed Mohamed, El Mahdi, Hoda Saleh, Khatatbeh, Moawiah, Ibrahiem, Afaf Taha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786528/
https://www.ncbi.nlm.nih.gov/pubmed/35083113
http://dx.doi.org/10.1155/2022/9993496
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author Ghorab, Doaa Shams-Deen
Helaly, Ahmed Mohamed
El Mahdi, Hoda Saleh
Khatatbeh, Moawiah
Ibrahiem, Afaf Taha
author_facet Ghorab, Doaa Shams-Deen
Helaly, Ahmed Mohamed
El Mahdi, Hoda Saleh
Khatatbeh, Moawiah
Ibrahiem, Afaf Taha
author_sort Ghorab, Doaa Shams-Deen
collection PubMed
description Diffuse large B cell lymphoma is the most common type of lymphoma in Egypt with an unfavorable prognosis. The tumor microenvironment is rich in immune response either T cells or macrophages. The current study is aimed at testing CD4, CD8, CD68, and MMP9 immunohistochemistry of DLBCL activities with the prognosis of the tumor. The results showed no positive relation between T cell and macrophage reaction to the tumor prognosis suggesting that this reaction is part of the tumor process and not a defense mechanism from the surrounding stroma.
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spelling pubmed-87865282022-01-25 Prognostic Role of Tumor Microenvironment in DLBCL and Relation to Patients' Clinical Outcome: A Clinical and Immunohistochemical Study Ghorab, Doaa Shams-Deen Helaly, Ahmed Mohamed El Mahdi, Hoda Saleh Khatatbeh, Moawiah Ibrahiem, Afaf Taha Anal Cell Pathol (Amst) Research Article Diffuse large B cell lymphoma is the most common type of lymphoma in Egypt with an unfavorable prognosis. The tumor microenvironment is rich in immune response either T cells or macrophages. The current study is aimed at testing CD4, CD8, CD68, and MMP9 immunohistochemistry of DLBCL activities with the prognosis of the tumor. The results showed no positive relation between T cell and macrophage reaction to the tumor prognosis suggesting that this reaction is part of the tumor process and not a defense mechanism from the surrounding stroma. Hindawi 2022-01-17 /pmc/articles/PMC8786528/ /pubmed/35083113 http://dx.doi.org/10.1155/2022/9993496 Text en Copyright © 2022 Doaa Shams-Deen Ghorab et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ghorab, Doaa Shams-Deen
Helaly, Ahmed Mohamed
El Mahdi, Hoda Saleh
Khatatbeh, Moawiah
Ibrahiem, Afaf Taha
Prognostic Role of Tumor Microenvironment in DLBCL and Relation to Patients' Clinical Outcome: A Clinical and Immunohistochemical Study
title Prognostic Role of Tumor Microenvironment in DLBCL and Relation to Patients' Clinical Outcome: A Clinical and Immunohistochemical Study
title_full Prognostic Role of Tumor Microenvironment in DLBCL and Relation to Patients' Clinical Outcome: A Clinical and Immunohistochemical Study
title_fullStr Prognostic Role of Tumor Microenvironment in DLBCL and Relation to Patients' Clinical Outcome: A Clinical and Immunohistochemical Study
title_full_unstemmed Prognostic Role of Tumor Microenvironment in DLBCL and Relation to Patients' Clinical Outcome: A Clinical and Immunohistochemical Study
title_short Prognostic Role of Tumor Microenvironment in DLBCL and Relation to Patients' Clinical Outcome: A Clinical and Immunohistochemical Study
title_sort prognostic role of tumor microenvironment in dlbcl and relation to patients' clinical outcome: a clinical and immunohistochemical study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786528/
https://www.ncbi.nlm.nih.gov/pubmed/35083113
http://dx.doi.org/10.1155/2022/9993496
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