Structurally-discovered KLF4 variants accelerate and stabilize reprogramming to pluripotency

Non-genetically modified somatic cells can only be inefficiently and stochastically reprogrammed to pluripotency by exogenous expression of reprogramming factors. Low competence of natural reprogramming factors may prevent the majority of cells to successfully and synchronously reprogram. Here we sc...

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Detalles Bibliográficos
Autores principales: Borisova, Evgeniia, Nishimura, Ken, An, Yuri, Takami, Miho, Li, Jingyue, Song, Dan, Matsuo-Takasaki, Mami, Luijkx, Dorian, Aizawa, Shiho, Kuno, Akihiro, Sugihara, Eiji, Sato, Taka-aki, Yumoto, Fumiaki, Terada, Tohru, Hisatake, Koji, Hayashi, Yohei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786646/
https://www.ncbi.nlm.nih.gov/pubmed/35106457
http://dx.doi.org/10.1016/j.isci.2021.103525

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