A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection

Emerging evidence indicates that both neutralizing and Fc-mediated effector functions of antibodies contribute to protection against SARS-CoV-2. It is unclear whether Fc-effector functions alone can protect against SARS-CoV-2. Here, we isolated CV3-13, a non-neutralizing antibody, from a convalescen...

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Detalles Bibliográficos
Autores principales: Beaudoin-Bussières, Guillaume, Chen, Yaozong, Ullah, Irfan, Prévost, Jérémie, Tolbert, William D., Symmes, Kelly, Ding, Shilei, Benlarbi, Mehdi, Gong, Shang Yu, Tauzin, Alexandra, Gasser, Romain, Chatterjee, Debashree, Vézina, Dani, Goyette, Guillaume, Richard, Jonathan, Zhou, Fei, Stamatatos, Leonidas, McGuire, Andrew T., Charest, Hughes, Roger, Michel, Pozharski, Edwin, Kumar, Priti, Mothes, Walther, Uchil, Pradeep D., Pazgier, Marzena, Finzi, Andrés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786652/
https://www.ncbi.nlm.nih.gov/pubmed/35123652
http://dx.doi.org/10.1016/j.celrep.2022.110368

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