Recombinant human interferon-α1b inhibits SARS-CoV-2 better than interferon-α2b in vitro

• A comprehensive evaluation method for anti-SARS-CoV-2 drugs was established based on qPCR, TCID(50), and immunofluorescence. • A significant antiviral effect of rHuIFN-α1b was shown in Vero and Calu-3 ​cells. • rHuIFN-α1b has a good potential in the application of anti-COVID-19 therapy.

Detalles Bibliográficos
Autores principales: Shi, Danrong, Chen, Keda, Lu, Xiangyun, Cheng, Linfang, Weng, Tianhao, Liu, Fumin, Wu, Nanping, Li, Lanjuan, Yao, Hangping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wuhan Institute of Virology, Chinese Academy of Sciences 2022
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786678/
https://www.ncbi.nlm.nih.gov/pubmed/35597770
http://dx.doi.org/10.1016/j.virs.2022.01.031
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author Shi, Danrong
Chen, Keda
Lu, Xiangyun
Cheng, Linfang
Weng, Tianhao
Liu, Fumin
Wu, Nanping
Li, Lanjuan
Yao, Hangping
author_facet Shi, Danrong
Chen, Keda
Lu, Xiangyun
Cheng, Linfang
Weng, Tianhao
Liu, Fumin
Wu, Nanping
Li, Lanjuan
Yao, Hangping
author_sort Shi, Danrong
collection PubMed
description • A comprehensive evaluation method for anti-SARS-CoV-2 drugs was established based on qPCR, TCID(50), and immunofluorescence. • A significant antiviral effect of rHuIFN-α1b was shown in Vero and Calu-3 ​cells. • rHuIFN-α1b has a good potential in the application of anti-COVID-19 therapy.
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spelling pubmed-87866782022-01-25 Recombinant human interferon-α1b inhibits SARS-CoV-2 better than interferon-α2b in vitro Shi, Danrong Chen, Keda Lu, Xiangyun Cheng, Linfang Weng, Tianhao Liu, Fumin Wu, Nanping Li, Lanjuan Yao, Hangping Virol Sin Letter • A comprehensive evaluation method for anti-SARS-CoV-2 drugs was established based on qPCR, TCID(50), and immunofluorescence. • A significant antiviral effect of rHuIFN-α1b was shown in Vero and Calu-3 ​cells. • rHuIFN-α1b has a good potential in the application of anti-COVID-19 therapy. Wuhan Institute of Virology, Chinese Academy of Sciences 2022-01-25 /pmc/articles/PMC8786678/ /pubmed/35597770 http://dx.doi.org/10.1016/j.virs.2022.01.031 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Letter
Shi, Danrong
Chen, Keda
Lu, Xiangyun
Cheng, Linfang
Weng, Tianhao
Liu, Fumin
Wu, Nanping
Li, Lanjuan
Yao, Hangping
Recombinant human interferon-α1b inhibits SARS-CoV-2 better than interferon-α2b in vitro
title Recombinant human interferon-α1b inhibits SARS-CoV-2 better than interferon-α2b in vitro
title_full Recombinant human interferon-α1b inhibits SARS-CoV-2 better than interferon-α2b in vitro
title_fullStr Recombinant human interferon-α1b inhibits SARS-CoV-2 better than interferon-α2b in vitro
title_full_unstemmed Recombinant human interferon-α1b inhibits SARS-CoV-2 better than interferon-α2b in vitro
title_short Recombinant human interferon-α1b inhibits SARS-CoV-2 better than interferon-α2b in vitro
title_sort recombinant human interferon-α1b inhibits sars-cov-2 better than interferon-α2b in vitro
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786678/
https://www.ncbi.nlm.nih.gov/pubmed/35597770
http://dx.doi.org/10.1016/j.virs.2022.01.031
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